Dopamine inhibits 32P incorporation into phosphatidylinositol in the anterior pituitary gland of the rat

P L CanonicoR M MacLeod


The in vitro effect of dopamine, haloperidol and pimozide on 32Pi incorporation into phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine by anterior pituitary glands was studied. Dopamine decreased the incorporation of 32Pi into phosphatidylinositol in a dose-related manner without affecting phosphatidylcholine and phosphatidylethanolamine. Haloperidol and pimozide did not modify 32Pi incorporation into these phospholipids by themselves but completely reversed the inhibitory effect of dopamine on phosphatidylinositol. The inhibition of 32Pi incorporation into phosphatidylinositol synthesis in the presence of 500 nM dopamine was significant at 20 min of incubation and maximal at 30 min. The possibility that a decrease in phosphatidylinositol cleavage and turnover may be involved in the inhibitory regulation of prolactin secretion by DA is suggested.


Jan 1, 1991·Journal of Molecular Neuroscience : MN·Z Elazar, S Fuchs
Feb 1, 1989·Trends in Pharmacological Sciences·L Vallar, J Meldolesi
Jul 1, 1984·Molecular and Cellular Endocrinology·A M JuddR M MacLeod
Feb 1, 1984·Molecular and Cellular Endocrinology·J L TurgeonD A Walsh
May 1, 1985·Molecular and Cellular Endocrinology·K KoikeR M MacLeod
Nov 1, 1987·Molecular and Cellular Endocrinology·H B Niznik
Sep 10, 1990·Molecular and Cellular Endocrinology·S I KuanR M MacLeod
Mar 15, 1988·Biochemical and Biophysical Research Communications·I S LoginR M MacLeod
Mar 1, 1983·Clinics in Endocrinology and Metabolism·M J Cronin, W S Evans
Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
May 1, 1983·The American Journal of Physiology·M J CroninE L Hewlett

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