Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty

Biology of Reproduction
Bernadette VidalS Dufour

Abstract

In various adult teleost fishes, LH ovulatory peak is under a dual neurohormonal control that is stimulatory by GnRH and inhibitory by dopamine (DA). We investigated whether DA could also be involved in the inhibitory control of LH at earlier steps of gametogenesis by studying the model of the European eel, Anguilla anguilla, which remains at a prepubertal stage until the oceanic reproductive migration. According to a protocol previously developed in the striped bass, eels received sustained treatments with GnRH agonist (GnRHa), DA-receptor antagonist (pimozide), and testosterone (T) either alone or in combination. Only the triple treatment with T, GnRHa, and pimozide could trigger dramatic increases in LH synthesis and release as well as in plasma vitellogenin levels and a stimulation of ovarian vitellogenesis. Thus, in the prepubertal eel, removal of DA inhibition is required for triggering GnRH-stimulated LH synthesis and release as well as ovarian development. To locate the anatomical support for DA inhibition, the distribution of tyrosine hydroxylase (TH) in the brain and pituitary was studied by immunocytochemistry. Numerous TH-immunoreactive cell bodies were observed in the preoptic anteroventral nucleus, with a dense tr...Continue Reading

References

Mar 1, 1983·General and Comparative Endocrinology·S DufourY A Fontaine
Dec 1, 1984·Journal of Pharmaceutical Sciences·S BenitaC Thies
Aug 1, 1980·The Journal of Clinical Endocrinology and Metabolism·C A HusemanI G Schneider
Feb 1, 1994·General and Comparative Endocrinology·J Sotowska-BrochockaP Licht
Aug 8, 1997·Molecular and Cellular Endocrinology·Y S HuangS Dufour
Feb 13, 2003·Molecular and Cellular Endocrinology·A VetillardT Bailhache
Apr 17, 2003·International Review of Cytology·Zvi YaronBerta Levavi-Sivan
Oct 11, 2003·Science·Richard Stone

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Citations

Apr 1, 2005·Fish Physiology and Biochemistry·J N NocilladoA Elizur
May 7, 2005·Molecular and Cellular Endocrinology·Berta Levavi-SivanAyelet Avitan
Jul 12, 2008·BMC Physiology·Arjan P PalstraGuido Eejm van den Thillart
Apr 15, 2010·Fish Physiology and Biochemistry·Arjan P Palstra, Guido E E J M van den Thillart
Jun 2, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Fabien PierronJean-Charles Massabuau
Oct 6, 2012·General and Comparative Endocrinology·H MigaudA Davie
Nov 19, 2011·General and Comparative Endocrinology·Peter PodhorecJan Kouril
Sep 10, 2014·Environmental Science & Technology·Fabien PierronMagalie Baudrimont
Nov 30, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·José M GuzmánEvaristo L Mañanós
Sep 22, 2009·General and Comparative Endocrinology·Arjan P PalstraGuido E E J M van den Thillart
Aug 19, 2009·General and Comparative Endocrinology·B Levavi-SivanJ J Lareyre
May 16, 2009·General and Comparative Endocrinology·Geir Lasse TarangerTom Hansen
Jul 29, 2008·Molecular and Cellular Endocrinology·Jason T PopeskuVance L Trudeau
Jun 20, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Dane M NewmanBrett A Ingram
Apr 25, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·V van GinnekenG van den Thillart
Feb 28, 2007·General and Comparative Endocrinology·Marie-Emilie SébertSylvie Dufour
Sep 30, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Christoffer RozenfeldDavid Mazurais
Nov 3, 2006·Molecular and Cellular Endocrinology·Josephine N NocilladoBerta Levavi-Sivan
May 14, 2005·Annals of the New York Academy of Sciences·S DufourC Pasqualini
Aug 27, 2010·Journal of Fish Biology·S DufourC Pasqualini
Apr 23, 2014·Reproduction in Domestic Animals = Zuchthygiene·D S PeñarandaJ F Asturiano
May 3, 2005·General and Comparative Endocrinology·Joseph AizenHanna Rosenfeld
May 3, 2005·General and Comparative Endocrinology·Finn-Arne WeltzienSylvie Dufour
Apr 7, 2015·General and Comparative Endocrinology·José M GuzmánPenny Swanson
May 29, 2014·Physiology & Behavior·Bruno Garcia MontagniniDaniela Cristina Ceccatto Gerardin
Aug 22, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Erik BurgerhoutGuido E E J M van den Thillart

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Methods Mentioned

BETA
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light microscopy

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