Dopamine inhibits mitral/tufted--> granule cell synapses in the frog olfactory bulb

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ian G DavisonKerry R Delaney

Abstract

Synaptic interactions between the dendrites of mitral/tufted (MT) and granule cells (GCs) in the olfactory bulb are important for the determination of spatiotemporal firing patterns of MTs, which form an odor representation passed to higher brain centers. These synapses are subject to modulation from several sources originating both within and outside the bulb. We show that dopamine, presumably released by TH-positive local interneurons, reduces synaptic transmission from MTs to GCs. MT neurons express D2-like receptors (D2Rs), and both dopamine and the D2 agonist quinpirole decrease EPSC amplitude at the MT--> GC synapse. D2R activation also increases paired pulse facilitation and decreases the frequency of action potential-independent spontaneous miniature EPSCs in GCs, consistent with an effect on MT glutamate release downstream from Ca2+ influx. Analysis of spike-evoked Ca2+ transients in MT lateral dendrites additionally shows that quinpirole reduces Ca2+ influx preferentially at distal locations, possibly by reducing dendritic excitability via increased transient K+ channel availability. When the OB is activated physiologically by using odor stimuli, blocking D2Rs increases the power of GABA(A)-dependent oscillations in t...Continue Reading

Citations

Oct 17, 2009·Zoological Science·Takafumi KawaiHeather Eisthen
Feb 26, 2005·The Journal of Physiology·Angela PignatelliOttorino Belluzzi
Feb 16, 2008·The Journal of Physiology·Diogo O Pimentel, Troy W Margrie
Sep 30, 2005·The European Journal of Neuroscience·María Gutièrrez-MecinasFrancisco José Martínez-Guijarro
Aug 8, 2006·Seminars in Cell & Developmental Biology·Veronica Egger, Nathaniel N Urban
Jul 22, 2005·Journal of Neurophysiology·Michelino PuopoloElio Raviola
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Oct 29, 2020·Frontiers in Cellular Neuroscience·Kirill S KorshunovPaul Q Trombley
Apr 7, 2021·Integrative and Comparative Biology·Matheus Macedo-Lima, Luke Remage-Healey
Mar 23, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J Bradley

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