Abstract
While neuronal activity is important in CNS development, little is known of the behaviour of the actual neurotransmitters released during this period. None the less, indirect evidence has suggested that the neurotransmitter dopamine actually has a morphogenic role. This study is the first attempt to monitor directly and in real-time, the release of dopamine from midbrain neurons developing as an isolated organotypic slice culture. The observed release of dopamine was both spontaneous and synchronized and occurred with an average periodicity that is two orders of magnitude longer than the characteristic neuronal discharge activity of midbrain dopamine cells. Moreover, elevations in the extracellular concentrations of dopamine were markedly more prolonged in these and other developing systems than in axon terminal regions in mature striatum in which dopaminergic innervation is fully established. Thus, dopamine may have an action in developing circuits over spatial and temporal scales that vastly exceed those in mature, synaptic-like transmission.
References
Nov 1, 1992·Neuroscience·K T KawagoeR M Wightman
Dec 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·N LimbergerK Starke
Jun 21, 1991·Brain Research. Developmental Brain Research·P A RaoJ N Joyce
May 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·W R Gibb, A J Lees
May 17, 1991·Science·M MeisterC J Shatz
Jun 3, 1991·FEBS Letters·A Malgaroli, J Meldolesi
Jan 1, 1990·Psychopharmacology·M G KoltaR R Holson
Mar 1, 1987·Journal of Neurochemistry·O Barochovsky, H F Bradford
Nov 1, 1988·Neuroscience·P D Shepard, D C German
Feb 15, 1988·Experientia·T J Rink
Jan 1, 1988·Journal of Neuroscience Research·D P McCobbS B Kater
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K L LankfordW L Klein
Sep 3, 1986·Brain Research·J A StamfordJ Millar
May 1, 1984·Neuroscience·L A ChiodoB S Bunney
Apr 20, 1995·Nature·R O WongC J Shatz
Sep 1, 1994·Neuroscience·U B SchambraR T Fremeau
Jan 1, 1995·Neuron·R YusteL C Katz
Mar 10, 1995·The Journal of Biological Chemistry·J M Finnegan, R M Wightman
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·B C SwarzenskiR D Todd
Jan 3, 1994·Neuroscience Letters·T AvidorD Atlas
Jan 1, 1993·Biological Signals·M Kraus, B Wolf
Jan 1, 1995·Experimental Brain Research·B H SteensenJ D Lambert
Sep 29, 1995·Brain Research. Developmental Brain Research·C HolmesS A Greenfield
Citations
Oct 26, 1999·Journal of Neuroscience Research·H BecqJ P Herman
Sep 23, 2000·Brain Research. Molecular Brain Research·E KüppersC Beyer
Jan 4, 2001·Neurochemistry International·V Leviel
Jan 3, 2003·Neurochemistry International·Heike FrankePeter Illes
Jun 26, 1999·The European Journal of Neuroscience·F Rougé-PontP V Piazza
Aug 16, 2008·The European Journal of Neuroscience·Trine R LarsenJan B Gramsbergen
Sep 24, 2004·The European Journal of Neuroscience·Stephanie J CraggMark D Bevan
Jun 10, 2004·Neurochemistry International·Christopher D Kroenke, Jeffrey J Neil
Jun 23, 2004·Neuron·Michael J BecksteadJohn T Williams
Jul 28, 1999·The Journal of Comparative Neurology·B S KirchhofA R Mercer
Mar 31, 2004·Neuroscience·F DelisP Giompres
Jun 16, 2004·Journal of Neuroscience Methods·Jennifer L PetersSusan R Sesack
Sep 12, 2018·Journal of Neurochemistry·Andrew G YeeJanusz Lipski