Dopamine-mediated MK-801-induced elevation in food-based extinction responding in rats and associated changes in region-specific phosphorylated ERK.

Psychopharmacology
Matthew R HolahanDelaney D Hines

Abstract

The current study examined the effect of the noncompetitive N-methyl-D: -aspartate (NMDA) receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) on the extinction of food-based operant responding. Experiments were carried out to determine (1) the nature of the elevated responding when rats were under the influence of MK-801, (2) the effect of combined and separate D1- and D2-like dopaminergic antagonists (SCH 23390 and haloperidol) on this MK-801-induced behavioral effect and (3) the neural correlates on and off MK-801 using immunohistochemical localization of the phosphorylated forms of the extracellular signal-regulated kinase-1 and -2. Male Long Evans rats were trained using operant conditioning procedures then treated with the various compounds, and resultant extinction pressing was measured. A moderate dose (0.1 mg/kg) of MK-801 produced a persistent, elevated lever pressing throughout the entire 30-min extinction session. When animals were pretreated with combined or separate dopamine (DA) D1- or D2-like receptor antagonists, extinction responding under MK-801 was significantly reduced. Examination of pERK1/2 labeling in MK-801-treated animals showed reduced staining in the i...Continue Reading

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Citations

Apr 25, 2012·Behavioural Brain Research·Natalia Gindri FiorenzaJociane C Myskiw
Feb 23, 2012·Synapse·Frédéric Huppé-Gourgues, Patricio O'Donnell
May 4, 2013·Neurobiology of Learning and Memory·Charlotte R Flavell, Jonathan L C Lee
Jan 9, 2014·Pharmacological Reports : PR·Marzena MaćkowiakKrzysztof Wędzony

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