Dopamine mediation of the feeding response to violations of spatial and temporal expectancies

Behavioural Brain Research
Mitchell F RoitmanI L Bernstein

Abstract

The present studies were aimed at further characterizing the role of DA in motivation. Rats, conditioned to expect food in one environment and no food in another, all received food on the test night. Those in the environment in which food was unexpected ate four times as much as those eating where food was expected. The overeating was eliminated by administration of the D2 antagonist raclopride. Another expectancy, timing of light offset in rats entrained to a fixed light--dark cycle, was violated by unexpectedly turning the lights off 1 h early. This provoked an elevation in food intake, which was also eliminated by the administration of raclopride. Feeding in two other situations not involving violation of expectancies (food deprivation; normal light offset) was unaffected by DA antagonism. These findings support the idea that DA signals errors in expectancy and that DA signaling is necessary for certain behavioral responses to unexpected events.

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Citations

Mar 25, 2011·Psychopharmacology·Matthew A AlbrechtFlavie Waters
Jul 23, 2010·Journal of Psychoactive Drugs·Yijun LiuMark S Gold
May 19, 2010·Pharmacology, Biochemistry, and Behavior·Mitchell F RoitmanHenry R Wolfe
Jun 15, 2007·Appetite·Eric G Krause, Randall R Sakai
Mar 24, 2007·Behavioural Brain Research·Harry N Shair
Jun 12, 2014·Developmental Psychobiology·Harry N Shair
Feb 25, 2015·Journal of Neurochemistry·Jackson J ConeMitchell F Roitman
Feb 23, 2007·Nature·C R RabyN S Clayton
Jul 17, 2004·Proceedings. Biological Sciences·J Matthias StarckPetra Linke
Mar 5, 2003·The International Journal of Eating Disorders·Nora D VolkowNaomi Pappas

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