Dopamine modulates graded and spike-evoked synaptic inhibition independently at single synapses in pyloric network of lobster

Journal of Neurophysiology
A AyaliR M Harris-Warrick

Abstract

Bath application of dopamine (DA) modifies the rhythmic motor pattern generated by the pyloric network in the stomatogastric ganglion of the spiny lobster, Panulirus interruptus. Synaptic transmission between network members is an important target of DA action. All pyloric neurons employ both graded transmitter release and action-potential-mediated synaptic inhibition. DA was previously shown to alter the graded synaptic strength of every pyloric synapse. In this study, we compared DA's effects on action-potential-mediated and graded synaptic inhibition at output synapses of the lateral pyloric (LP) neuron. At each synapse the postsynaptic cell tested was isolated from other descending and pyloric synaptic inputs. DA caused a reduction in the size of the LP spike-evoked inhibitory postsynaptic potentials (IPSPs) in the pyloric dilator (PD) neuron. The change in IPSP size was significantly and linearly correlated with DA-induced reduction in the input resistance of the postsynaptic PD neuron. In contrast, graded inhibition, tested in the same preparations after superfusing the stomatogastric ganglion (STG) with tetrodotoxin (TTX), was consistently enhanced by DA. DA shifted the amplitude of spike-evoked IPSPs in the same directi...Continue Reading

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Citations

Aug 9, 2003·Journal of Neurophysiology·Bruce R JohnsonRonald M Harris-Warrick
Apr 23, 2005·The European Journal of Neuroscience·Günter GisselmannHanns Hatt
Mar 1, 2005·The European Journal of Neuroscience·Attila SzücsAllen I Selverston
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Oct 26, 2016·Journal of Computational Neuroscience·Jannetta S Steyn, Peter Andras
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Jul 15, 2005·Journal of Neurophysiology·Matthias GruhnRonald M Harris-Warrick
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