Dopamine modulates the rest period length without perturbation of its power law distribution in Drosophila melanogaster.

PloS One
Taro UenoKazuhiko Kume

Abstract

We analyzed the effects of dopamine signaling on the temporal organization of rest and activity in Drosophila melanogaster. Locomotor behaviors were recorded using a video-monitoring system, and the amounts of movements were quantified by using an image processing program. We, first, confirmed that rest bout durations followed long-tailed (i.e., power-law) distributions, whereas activity bout durations did not with a strict method described by Clauset et al. We also studied the effects of circadian rhythm and ambient temperature on rest bouts and activity bouts. The fraction of activity significantly increased during subjective day and at high temperature, but the power-law exponent of the rest bout distribution was not affected. The reduction in rest was realized by reduction in long rest bouts. The distribution of activity bouts did not change drastically under the above mentioned conditions. We then assessed the effects of dopamine. The distribution of rest bouts became less long-tailed and the time spent in activity significantly increased after the augmentation of dopamine signaling. Administration of a dopamine biosynthesis inhibitor yielded the opposite effects. However, the distribution of activity bouts did not contrib...Continue Reading

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Citations

Mar 13, 2014·Proceedings. Biological Sciences·Victoria J WearmouthDavid W Sims
Oct 16, 2012·Nature Neuroscience·Taro UenoKazuhiko Kume
Sep 19, 2014·Frontiers in Behavioral Neuroscience·Taro Ueno, Kazuhiko Kume
Aug 24, 2018·PloS One·Guadalupe CascallaresPablo M Gleiser
Jun 13, 2015·Royal Society Open Science·Andrew M ReynoldsJason W Chapman
Apr 29, 2014·Experimental Animals·Shinya Yamamoto, Elaine S Seto
Apr 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Timothy D WigginLeslie C Griffith
Mar 15, 2015·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Taro Ueno, Kazuhiko Kume
Dec 27, 2016·Royal Society Open Science·Paulo F C TillesPaulo L Natti
Apr 8, 2017·Scientific Reports·Diego A GuzmánJackelyn M Kembro
Oct 23, 2020·Scientific Reports·John EllisSergei Petrovskii
Mar 21, 2021·Communications Biology·Xiaochan XuChao Tang

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Methods Mentioned

BETA
transgenic

Software Mentioned

Labview
R

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