Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration

Synapse
Junchao TongStephen J Kish

Abstract

Binding of (+)-[11C]DTBZ (dihydrotetrabenazine) to the striatal vesicular monoamine transporter (VMAT2) is widely considered to be a stable marker of dopamine neurone integrity. However, we now find that specific binding of a tracer dose of (+)-[11C]DTBZ is modestly increased in rat striatum following dopamine depletion with alpha-methyl-p-tyrosine (alpha-MPT, +14%) or d-amphetamine (d-AMPH, 20 mg/kg, +12%) and decreased following dopamine elevation with gamma-hydroxybutyrate (GHB, -16%) or levodopa (-20%). We suggest that in vivo (+)-[11C]DTBZ binding in imaging studies is subject to competition by vesicular dopamine and, in this respect, is not a "stable" dopamine biomarker as is generally assumed.

References

Oct 1, 1971·Journal of Neurochemistry·P F SpanoG L Gessa
Nov 1, 2000·Nuclear Medicine and Biology·A A WilsonS Houle
Apr 24, 2003·Synapse·Raúl De La Fuente-FernándezA Jon Stoessl
Mar 7, 2006·Psychopharmacology·Chris-Ellyn JohansonCharles R Schuster
Jul 13, 2006·The Journal of Pharmacology and Experimental Therapeutics·John S PartillaRichard B Rothman
Feb 2, 2008·Annals of Neurology·W R Wayne MartinMichael Schulzer

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Citations

Jan 29, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·A Jon Stoessl
Oct 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anne M LandauDoris J Doudet
Aug 11, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Vesna SossiRaúl de la Fuente-Fernández
Feb 14, 2012·Neuro-degenerative Diseases·Anne M LandauDoris J Doudet
Feb 2, 2016·Expert Review of Neurotherapeutics·Musleh A Algarni, A Jon Stoessl
Sep 1, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Isabelle BoileauStephen J Kish
Feb 4, 2010·Nuclear Medicine and Biology·Michael R KilbournKirk A Frey
Apr 28, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Junchao TongStephen J Kish
Apr 25, 2009·Synapse·Raúl de la Fuente-FernándezA Jon Stoessl
Aug 29, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Pankaj A Agarwal, A Jon Stoessl
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·A Jon StoesslDavid Eidelberg
Sep 15, 2018·Frontiers in Neuroscience·Fatemeh N Emamzadeh, Andrei Surguchov
Oct 26, 2018·Scientific Reports·Thea P LillethorupAnne M Landau

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