Jul 5, 2006

Dopamine modulation of prefrontal cortical interneurons changes during adolescence

Cerebral Cortex
Kuei-Yuan Tseng, Patricio O'Donnell

Abstract

Adolescence is marked by profound psychological and neuroendocrine changes. Cognitive functions that depend on the prefrontal cortex and dopamine (DA), such as decision making, are acquired or refined during adolescence; yet, little is known about how neural circuits mature in the transition to adulthood. Here, we conducted electrophysiological recordings in rat brain slices, unveiling an enhancement of the excitability of interneurons, which are important for cortical network activity, by D(1) and D(2) DA receptors. The D(2) effect was observed in slices from adult (postnatal day [PD] > 50) but not preadolescent (PD < 36) animals suggesting a possible neural substrate for the maturation of DA-dependent prefrontal cortical functions during or after adolescence and identifying a critical neural population that could be involved in the periadolescent onset of neuropsychiatric disorders, such as schizophrenia.

Mentioned in this Paper

Prefrontal Cortex
Schizophrenia
Neurosecretory Systems
Biologic Development
Senility
Neuronal Plasticity
Structure of Cortex of Kidney
Interneurons
Dopamine Measurement
Dopamine

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.