Dopamine natriuresis in salt-repleted, water-loaded humans: a dose-response study

British Journal of Clinical Pharmacology
N V OlsenP P Leyssac

Abstract

The purpose of the present study was to define the dose-response relationship between exogenous dopamine and systemic haemodynamics, renal haemodynamics, and renal excretory function at infusion rates in the range 0 to 12.5 microg kg(-1) min(-1) in normal volunteers. While undergoing water diuresis, eight subjects were infused with 0, 1, 2, 3, 5, 7.5, 10 or 12.5 microg of dopamine kg(-1) min(-1) over 2 h in a randomized and double-blind fashion. On each study day, renal clearance studies were performed during a 1 h baseline period and subsequently during the second 1 h infusion period. Lithium clearance (CL(Li)) was used to estimate proximal tubular outflow. Cardiac output increased with the four highest doses. Mean arterial pressure followed a biphasic pattern with a decrease during the two lowest doses and a dose-dependent increase from the 7.5 microg kg(-1) min(-1) dose onwards. Effective renal plasma flow increased with all doses of dopamine, but peaked with the 3 microg kg(-1) min(-1) infusion rate [from 617 (585-649) ml min(-1) with placebo to 915 (824-1006) ml min(-1) (means with 95% CI, P<0.001)]. None of the doses changed glomerular filtration rate (GFR). Sodium clearance (CL(Na)) and CL(Li) were elevated with the four...Continue Reading

Citations

Nov 30, 2000·Anesthesiology Clinics of North America·J F O'Hara
May 31, 2012·Clinical and Experimental Pharmacology & Physiology·Adriano CaixetaGiora Weisz
May 3, 2007·American Journal of Veterinary Research·Monica RosatiWilliam C Sears
Dec 18, 2001·The Journal of Urology·Jerome F O'HaraAndrew C Novick
May 9, 2002·Expert Opinion on Investigational Drugs·Sheila A Doggrell
Aug 27, 1998·Hypertension·T Hussain, M F Lokhandwala
May 16, 2015·Journal of the American Society of Nephrology : JASN·Aruna R NatarajanPedro A Jose

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