Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

ELife
William MenegasMitsuko Watabe-Uchida

Abstract

Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, cortex, amygdala, etc) in mice. We found that most populations of dopamine neurons receive a similar set of inputs rather than forming strong reciprocal connections with their target areas. A common feature among most populations of dopamine neurons was the existence of dense 'clusters' of inputs within the ventral striatum. However, we found that dopamine neurons projecting to the posterior striatum were outliers, receiving relatively few inputs from the ventral striatum and instead receiving more inputs from the globus pallidus, subthalamic nucleus, and zona incerta. These results lay a foundation for understanding the input/output structure of the midbrain dopamine circuit and demonstrate that dopamine neurons projecting to the posterior striatum constitute a unique class of dopamine neurons regulated by different inputs.

References

Jan 1, 1978·Annual Review of Neuroscience·R Y Moore, F E Bloom
Oct 1, 1991·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Jul 1, 1982·Brain Research Bulletin·J H Fallon, S E Loughlin
Dec 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·P K MorrishD J Brooks
Jul 22, 1994·The Journal of Comparative Neurology·E Lynd-Balta, S N Haber
Mar 14, 1997·Science·W SchultzP R Montague
Jun 1, 1997·Experimental Brain Research·S MiyachiM K Rand
Apr 15, 1999·Annual Review of Neuroscience·C W Olanow, W G Tatton
Dec 4, 2003·Behavioural Brain Research·Harry B M UylingsBryan Kolb
Feb 3, 2004·The Journal of Comparative Neurology·Marina Goto, Larry W Swanson
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise
Jul 24, 2004·Trends in Neurosciences·Pieter VoornCyriel M A Pennartz
Aug 5, 2004·Brain : a Journal of Neurology·Chantal FrançoisLéon Tremblay
Jul 6, 2005·Neuron·Hannah M Bayer, Paul W Glimcher
Aug 6, 2005·The Journal of Comparative Neurology·Stefanie Geisler, Daniel S Zahm
Aug 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stéphane LehéricyJulien Doyon
Aug 30, 2005·Neuroscience and Biobehavioral Reviews·Daniel S Zahm
Jul 26, 2006·Genesis : the Journal of Genetics and Development·Cristina M BäckmanAndreas C Tomac
Nov 23, 2006·Nature Reviews. Neuroscience·Peter Redgrave, Kevin Gurney
Mar 9, 2007·Annals of the New York Academy of Sciences·Yasushi Kobayashi, Ken-Ichi Okada
Apr 6, 2007·Trends in Neurosciences·Anders Björklund, Stephen B Dunnett
May 25, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefanie GeislerDaniel S Zahm
Jun 30, 2007·Annual Review of Neuroscience·Wolfram Schultz

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Citations

Feb 9, 2016·Nature Neuroscience·Neir EshelNaoshige Uchida
Feb 11, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Natalia López-González del Rey, Javier Blesa
Nov 7, 2015·The Journal of Physiological Sciences : JPS·Takeshi KandaHiromasa Funato
Mar 12, 2016·Cell·Talia N LernerKarl Deisseroth
Oct 10, 2015·ELife·Amanda M Willard, Aryn H Gittis
Mar 26, 2016·Frontiers in Psychiatry·Idaira Oliva, Matthew J Wanat
May 31, 2016·Cell·Nicolas RenierMarc Tessier-Lavigne
May 25, 2016·Behavioral and Brain Functions : BBF·Kevin Lloyd, Peter Dayan
May 22, 2016·Journal of Neurochemistry·Daniela Maria Vogt WeisenhornWolfgang Wurst
Jun 24, 2016·The European Journal of Neuroscience·Xiong XiaoZuoren Wang
May 6, 2016·Annual Review of Neuroscience·Hailan Hu
Sep 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jill R CrittendenAnn M Graybiel
Oct 21, 2016·ELife·Hideyuki MatsumotoMitsuko Watabe-Uchida
Nov 2, 2016·The European Journal of Neuroscience·Wendy XinAntonello Bonci
Jan 24, 2017·Nature Neuroscience·Nicholas J EdwardsAntonello Bonci
Sep 7, 2016·Scientific Reports·Kristian H R Jensen, Rune W Berg
Mar 30, 2017·Nature Neuroscience·Bruno B Averbeck, Vincent D Costa
Nov 23, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Joo Han LeeJoung-Hun Kim
Feb 6, 2017·Journal of Neural Transmission·Okihide HikosakaHidetoshi Amita
Jan 21, 2017·Translational Neurodegeneration·Jing Pan, Huaibin Cai
Jan 6, 2017·Nature Reviews. Neuroscience·Marisela Morales, Elyssa B Margolis
Jun 29, 2017·The Journal of Comparative Neurology·Jonas BromsAnders Tingström
May 25, 2018·Annual Review of Biophysics·Viviana GradinaruKarl Deisseroth
Jan 10, 2018·Frontiers in Neural Circuits·Giorgio Rizzi, Kelly R Tan
May 2, 2018·Annual Review of Neuroscience·Claire N BedbrookViviana Gradinaru
Apr 27, 2018·Journal of Neuroscience Research·Floris G WouterloodJean-Michel Deniau
Aug 15, 2018·Nature Neuroscience·Jean-Francois PoulinRajeshwar Awatramani
Mar 30, 2016·Journal of Biomedical Optics·Ludovico SilvestriFrancesco Saverio Pavone
Jul 8, 2016·Nature Communications·Christian J NiedworokTroy W Margrie
Jan 19, 2019·Science·Ilaria CartaKamran Khodakhah
Jun 7, 2019·Nature Reviews. Neuroscience·Julia Cox, Ilana B Witten
Sep 17, 2019·Annual Review of Vision Science·Emmanouil FroudarakisAndreas S Tolias
Jun 28, 2019·Journal of Neurochemistry·Giuseppe GangarossaEmmanuel Valjent
Nov 22, 2019·Nature Protocols·Katsuhiko MatsumotoHiroki R Ueda
Jan 4, 2020·Nature Reviews. Neuroscience·Hiroki R UedaPhilipp J Keller

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Methods Mentioned

BETA
imaging techniques
light sheet microscopy

Software Mentioned

MATLAB
CUBIC
CLARITY
Elastix
OptiView
Ilastik

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