Dopamine, prediction error and associative learning: a model-based account

Network : Computation in Neural Systems
Andrew SmithShitij Kapur

Abstract

The notion of prediction error has established itself at the heart of formal models of animal learning and current hypotheses of dopamine function. Several interpretations of prediction error have been offered, including the model-free reinforcement learning method known as temporal difference learning (TD), and the important Rescorla-Wagner (RW) learning rule. Here, we present a model-based adaptation of these ideas that provides a good account of empirical data pertaining to dopamine neuron firing patterns and associative learning paradigms such as latent inhibition, Kamin blocking and overshadowing. Our departure from model-free reinforcement learning also offers: 1) a parsimonious distinction between tonic and phasic dopamine functions; 2) a potential generalization of the role of phasic dopamine from valence-dependent "reward" processing to valence-independent "salience" processing; 3) an explanation for the selectivity of certain dopamine manipulations on motivation for distal rewards; and 4) a plausible link between formal notions of prediction error and accounts of disturbances of thought in schizophrenia (in which dopamine dysfunction is strongly implicated). The model distinguishes itself from existing accounts by off...Continue Reading

References

Apr 1, 1977·Journal of Comparative and Physiological Psychology·P R Solomon
Feb 1, 1978·Behavioral Biology·E J RickertJ French
May 1, 1976·Animal Learning & Behavior·N J Mackintosh
Nov 1, 1992·Biological Psychiatry·S H JonesD R Hemsley
Nov 1, 1990·Psychological Bulletin·I Weiner
Oct 1, 1988·The Journal of Nervous and Mental Disease·I BaruchJ A Gray
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·I WeinerJ Feldon
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·I WeinerY Katz
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Jun 1, 1973·Psychological Bulletin·R E Lubow
Jul 1, 1973·Archives of General Psychiatry·D S Bell
Aug 1, 1994·Journal of Neurophysiology·J Mirenowicz, W Schultz
May 1, 1996·Schizophrenia Research·N R SwerdlowM A Geyer
Mar 14, 1997·Science·W SchultzP R Montague
Apr 1, 1997·Current Opinion in Neurobiology·W Schultz
Dec 24, 1997·Behavioural Brain Research·D Vaitl, O V Lipp
Jun 6, 1998·The British Journal of Psychiatry : the Journal of Mental Science·J H WilliamsJ N Rawlins
Jul 11, 1998·Journal of Neurophysiology·W Schultz
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Apr 9, 1999·Nature Neuroscience·J R Hollerman, W Schultz
Apr 24, 1999·Trends in Neurosciences·P RedgraveK Gurney
Mar 17, 2000·Brain Research. Brain Research Reviews·A A Grace
Mar 24, 2000·Cerebral Cortex·W SchultzJ R Hollerman
Mar 24, 2000·Cerebral Cortex·E T Rolls
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A PloghausP M Matthews
Sep 30, 2000·Brain Research. Brain Research Reviews·P C MoserP M Moran
Feb 13, 2001·Behavioural Brain Research·N A SchmajukJ A Gray

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Citations

Oct 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Y-Lan Boureau, Peter Dayan
Jul 9, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michal Arad, Ina Weiner
Sep 16, 2008·Schizophrenia Bulletin·Michael J Frank
Aug 1, 2009·Journal of Cognitive Neuroscience·Peter KrummenacherPeter Brugger
Feb 6, 2008·PLoS Computational Biology·Peter Dayan, Quentin J M Huys
Dec 15, 2010·PLoS Computational Biology·Daniel E Acuña, Paul Schrater
Feb 1, 2014·Physiology & Behavior·Anna E Creighton, Walter Wilczynski
Oct 23, 2012·Revista de psiquiatrí́a y salud mental·Guillermo LaheraJerónimo Sáiz-Ruiz
Mar 17, 2009·Cognition·Quentin J M Huys, Peter Dayan
Sep 4, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·P M MoranM A Reveley
Apr 11, 2012·The European Journal of Neuroscience·Zeb Kurth-NelsonA David Redish
Jun 24, 2008·Network : Computation in Neural Systems·Michael MoutoussisPeter Dayan
Dec 21, 2014·Frontiers in Neuroendocrinology·Ulrike StadlbauerUrs Meyer
Jun 12, 2016·Neuroscience and Biobehavioral Reviews·Rodrigo S FernándezMaría E Pedreira
Mar 1, 2012·Brain : a Journal of Neurology·Anne-Kathrin J FettLydia Krabbendam
Aug 15, 2012·Molecular Psychiatry·W T Carpenter, J M Davis
Jan 23, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Segev BarakIna Weiner
Jan 8, 2020·Schizophrenia Bulletin·Anna L MoonKerrie L Thomas
May 25, 2021·Frontiers in Behavioral Neuroscience·Brian KeyDeborah J Brown

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