Dopamine receptor D4 allele distribution in Amerindians: a reflection of past behavior differences?

American Journal of Physical Anthropology
Luciana Tovo-RodriguesMara H Hutz

Abstract

The DRD4 variable number of tandem repeats (VNTR) allele distribution of 172 Guarani (Kaiowá and Ñandeva subgroups) and Kaingang Brazilian Amerindians is reported. These results are integrated with those previously obtained for this ethnic group. Allele frequencies for the three populations are within the interval observed for 15 other Native American populations and show intermediate values between those observed in Amazonia and Patagonia. Significant differences in allele distribution between recent past hunter-gatherer and agriculturalist populations are observed, with an increase of the 7R allele among hunter-gatherers (P < 0.001). Analysis of molecular variance (AMOVA) and pairwise F(ST) data suggest three distinct sectors for the genetic landscape of Native South America: Andes, Center/Southeast region, and Amazonia. Common traits among hunter-gatherers such as novelty-seeking temperament, hyperactivity, and impulsivity could have been important and advantageous in new environments during America's prehistoric colonization.

References

Apr 1, 1987·Genetical Research·P PamiloW H Li
Jan 1, 1983·Journal of Molecular Evolution·M NeiY Tateno
Jun 1, 1993·Human Molecular Genetics·J B LichterK J Livak
Dec 24, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·P S JensenT Shapiro
Oct 17, 1998·Molecular Psychiatry·D C RoweI D Waldman
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·Mara H. HutzFrancisco M. Salzano
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yuan-Chun DingRobert K Moyzis
Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Henry Harpending, Gregory Cochran
Apr 13, 2004·American Journal of Human Genetics·E WangR K Moyzis
Feb 9, 2005·American Journal of Human Genetics·Matthew Stephens, Paul Scheet
May 14, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·D L GradyR K Moyzis
Jul 20, 2006·Journal of the Royal Society, Interface·Jonathan Williams, Eric Taylor
Oct 14, 2006·American Journal of Human Biology : the Official Journal of the Human Biology Council·Verónica L Martínez Marignac, Néstor O Bianchi
Jun 29, 2007·American Journal of Physical Anthropology·Sidia M Callegari-JacquesMara H Hutz
Jun 10, 2009·Human Genetics·Ian R GizerIrwin D Waldman

❮ Previous
Next ❯

Citations

Aug 31, 2013·PloS One·Vincenza BattagliaOrnella Semino
Feb 16, 2013·Genetics and Molecular Biology·Francisco M Salzano
Jul 1, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ana Julia Aguirre-SamudioLuis Medrano-González
Jan 16, 2021·International Journal of Molecular Sciences·Margarita A SazonovaIgor A Sobenin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.