PMID: 1332033Nov 1, 1992

Dopamine receptor subtypes colocalize in rat striatonigral neurons

Proceedings of the National Academy of Sciences of the United States of America
D J SurmeierS T Kitai


Dopaminergic neurons of the substantia nigra provide one of the major neuromodulatory inputs to the neostriatum. Recent in situ hybridization experiments have suggested that postsynaptic dopamine receptors are segregated in striatonigral and striatopallidal neurons. We have tested this hypothesis in acutely isolated, retrogradely labeled striatonigral neurons by examining the neuromodulatory effects of selective dopaminergic agonists on Na currents and by probing single-cell antisense RNA populations with dopamine receptor cDNAs. In most of the neurons examined (20/31), the application of the D1 dopamine receptor agonist SKF 38393 reduced evoked whole-cell Na+ current. The D2 agonists quinpirole and bromocriptine had mixed effects; in most neurons (23/42), whole-cell Na+ currents were reduced, but in others (8/42), currents were increased. In cell-attached patch recordings, bath application of SKF 38393 decreased currents as in whole-cell recordings, whereas quinpirole consistently (6/10) enhanced currents--suggesting that D2-like receptors could act through membrane delimited and non-delimited pathways. Changes in evoked current were produced by modulation of peak conductance and modest shifts in the voltage dependence of stea...Continue Reading


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Related Concepts

Quinpirole Hydrochloride
Biochemical Pathway
Exploration With a Probe
Dopamine D3 receptor
Drd3 protein, rat
Antisense RNA
Immunofluorescence Microscopy
Substantia Nigra Structure

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