PMID: 8986215Dec 1, 1996Paper

Dopamine receptors in the medial prefrontal cortex influence ethanol and sucrose-reinforced responding

Alcoholism, Clinical and Experimental Research
C W HodgeH H Samson

Abstract

This study tested the role of dopamine receptors in the medial prefrontal cortex (mPFC) in the onset, maintenance, and termination of ethanol and sucrose-reinforced responding. Two groups of Long Evans rats were trained to lever press on a fixed-ratio 4 schedule of reinforcement with 10% ethanol (n = 10) or 5% sucrose (n = 5) presented as the reinforcer. After implantation of injector guide cannulae, the D2/3 agonist quinpirole and the D2 antagonist raclopride were administered bilaterally into the mPFC before behavioral sessions. During control conditions, sucrose reinforcement maintained a 2-fold greater number of responses per session than did ethanol reinforcement. Quinpirole (10.0 micrograms/microliter) reduced total ethanol-reinforced responses by delaying response onset and decreasing the duration of responding, but had no effect on response maintenance (i.e., response rate). A higher dose of quinpirole (20.0 micrograms/microliter) decreased total sucrose responses by simultaneously decreasing duration and response rate, without altering response latency. Thus, the effects of quinpirole on ethanol and sucrose-reinforced responding were similar on response total and duration, but differential on response latency and rate....Continue Reading

References

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Citations

Jan 25, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Paula J BiceLucinda G Carr
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Aiko IkegamiChristine L Duvauchelle
Jan 13, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·E M Nakamura-PalaciosC F Gomes
Aug 15, 2000·Drug and Alcohol Dependence·R MalcolmK T Brady
Mar 26, 1998·Alcoholism, Clinical and Experimental Research·L J PorrinoH H Samson
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·K T Szeliga, K A Grant
Nov 12, 2005·Substance Use & Misuse·Alessandra Buonopane, Ismene L Petrakis
Nov 18, 2004·Alcoholism, Clinical and Experimental Research·Kimber L Price, Lawrence D Middaugh
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·Jason P SchroederClyde W Hodge
Dec 29, 2007·Alcoholism, Clinical and Experimental Research·Joyce BesheerClyde W Hodge
Feb 21, 2013·Alcoholism, Clinical and Experimental Research·Christina J SchierRueben A Gonzales
Feb 24, 2015·Alcoholism, Clinical and Experimental Research·Abigail E AgogliaClyde W Hodge
Sep 17, 2004·Pharmacology & Therapeutics·Rueben A GonzalesWilliam M Doyon
Feb 27, 2003·Alcoholism, Clinical and Experimental Research·Kalervo KiianmaaAndrey E Ryabinin
May 3, 2015·Pharmacology, Biochemistry, and Behavior·Paula Honório de Melo MartimianoManuela Figueiroa Lyra de Freitas
Feb 27, 2003·The European Journal of Neuroscience·Mufida El-GhundiSusan R George
Jul 12, 2016·Addiction Biology·Philippe PfeiferMathias Schreckenberger
Jul 21, 2016·Alcoholism, Clinical and Experimental Research·James M DohertyRueben A Gonzales
Apr 5, 2007·Reviews in the Neurosciences·Mufida El-GhundiSusan R George
Dec 1, 2017·Neuropharmacology·Anel A JaramilloJoyce Besheer

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