Dopamine-regulated phosphorylation of synaptic vesicle-associated proteins in rat neostriatum and substantia nigra

Neuroscience
S I WalaasPaul Greengard

Abstract

Dopamine, acting through dopamine D1 receptors and cyclic AMP-dependent protein kinase, has been found to increase the state of phosphorylation of the synaptic vesicle-associated phosphoproteins synapsin I and protein III in slices of rat neostriatum and substantia nigra. In the neostriatum, the effect of dopamine was mimicked by SKF 38393, a D2 receptor agonist, and was abolished by preincubation of the slices with fluphenazine or SCH 23390, antipsychotic drugs which are potent D1 receptor antagonists, but not by the D2 receptor antagonists l-sulpiride or spiroperidol. The maximal effect of dopamine in the neostriatum represented approximately 30-35% of the maximal effect induced by 8-bromo cyclic AMP, suggesting that a similar fraction of nerve terminals in the neostriatum may express the dopamine D1 receptor. Evidence for a small population of beta-adrenergic receptors regulating nerve terminal protein phosphorylation in the neostriatum, distinct from the D1 dopamine receptors, was also obtained. In the substantia nigra, the effect of dopamine also appeared to be mediated through a D1 dopamine receptor, since it was abolished by fluphenazine and SCH 23390. The maximal effect of dopamine in the substantia nigra represented ap...Continue Reading

References

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Citations

Jan 1, 1992·Experimental Brain Research·H Condé
Jan 1, 1993·Journal of Molecular Neuroscience : MN·S I Walaas, P Greengard
Jul 1, 1997·Mechanisms of Ageing and Development·I D LaviadaA Haro
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K D ParfittM D Browning
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S Y NahZ Vogel
Dec 27, 2005·Pharmacology, Biochemistry, and Behavior·Aung SiR Maleszka

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