Dopamine regulates cytokine secretion during innate and adaptive immune responses

International Immunology
Masaaki KawanoSho Matsushita

Abstract

Dopamine (DA) is synthesized by various immune cells. DA receptors (DARs), which comprise five isoforms, are expressed on the surface of these cells. Therefore, it is likely that DA plays a role in regulating innate and adaptive responses. However, the underlying molecular mechanism(s) is largely unknown. Here, we found that, during innate immune responses, DA suppressed secretion of IFN-γ, TNF-α and IL-1β, but promoted secretion of IL-10 and CXCL1 by lipopolysaccharide (LPS)-stimulated mouse splenocytes, suggesting that DA regulates cytokine secretion. Immune subset studies indicated that DA suppressed secretion of IFN-γ, TNF-α and IL-1β by NK cells, as well as secretion of TNF-α by neutrophils and monocytes; however, DA up-regulated IL-10 secretion by neutrophils, monocytes, B cells, macrophages (Mφs) and dendritic cells within the splenocyte population. In addition, DA up-regulated secretion of CXCL1 by LPS-stimulated NK cells and Mφs. Meanwhile, treatment with DAR agonists or antagonists suppressed secretion of inflammatory cytokines from LPS-stimulated splenocytes. Pre-treatment of LPS-stimulated splenocytes with the PI3K inhibitor wortmannin reversed DA-mediated suppression of IFN-γ secretion, indicating that DA regulates...Continue Reading

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Citations

May 12, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·S M Matt, P J Gaskill
Jun 6, 2020·The Journal of General Virology·Kikue SaikaMasaaki Kawano
Sep 26, 2020·Frontiers in Psychiatry·Anna DölpChristian Fleischhaker
Mar 18, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V MelnikovA N Boyko
Apr 27, 2021·Frontiers in Immunology·Yifei Feng, Yan Lu
May 18, 2021·Frontiers in Immunology·Diego CatalánOctavio Aravena
Aug 14, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M V MelnikovA N Boyko

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