Dopamine regulates stimulus generalization in the human hippocampus

ELife
Thorsten Kahnt, Philippe N Tobler

Abstract

The ability to generalize previously learned information to novel situations is fundamental for adaptive behavior. However, too wide or too narrow generalization is linked to neuropsychiatric disorders. Previous research suggests that interactions between the dopaminergic system and the hippocampus may play a role in generalization, but whether and how the degree of generalization can be modulated via these pathways is currently unknown. Here, we addressed this question in humans using pharmacology, functional magnetic resonance imaging, and computational modeling. Blocking dopamine D2-receptors (D2R) altered generalization behavior as revealed by an increased kurtosis of the generalization gradient, and a decreased width of model-derived generalization parameters. Moreover, D2R-blockade modulated similarity-based responses in the hippocampus and decreased midbrain-hippocampal connectivity, which in turn correlated with individual differences in generalization. These results suggest that dopaminergic activity in the hippocampus may relate to the degree of generalization and highlight a potential target for treatment.

References

Jan 1, 1987·Psychological Review·J M Pearce
Feb 1, 1967·Journal of Abnormal Psychology·A H Buss, E F Daniell
May 18, 1999·Animal Behaviour·S Ghirlanda, M Enquist
Oct 8, 1999·Behavioural Brain Research·H Eichenbaum
Mar 17, 2001·Nature Reviews. Neuroscience·H Eichenbaum
Jan 1, 1956·Journal of Experimental Psychology·N GUTTMAN, H I KALISH
Nov 1, 1959·Journal of Experimental Psychology·H M HANSON
Aug 18, 2006·Psychological Science·Michael J FrankTim Curran
Mar 9, 2007·Annals of the New York Academy of Sciences·Mauricio R Delgado
Jun 30, 2007·Annual Review of Neuroscience·Wolfram Schultz
Oct 12, 2007·Brain Research·C CasasolaD N Velázquez-Martínez
Aug 8, 2008·Learning & Behavior·John M PearceMark Haselgrove
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hidehiko TakahashiTetsuya Suhara
Sep 26, 2009·Neuron·Dharshan KumaranEleanor A Maguire
Oct 10, 2009·Learning & Behavior·Matthew G WisniewskiEduardo Mercado
Mar 3, 2010·Annual Review of Clinical Psychology·Ian H Gotlib, Jutta Joormann
Aug 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eitan SchechtmanRony Paz
Sep 11, 2010·Trends in Cognitive Sciences·Daphna Shohamy, R Alison Adcock
Dec 2, 2010·Journal of the Experimental Analysis of Behavior·Adam Derenne
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gerhard JochamMarkus Ullsperger
Apr 5, 2011·Annual Review of Neuroscience·Larry R Squire, John T Wixted
May 11, 2011·Neuron·Thorsten KahntJohn-Dylan Haynes
Oct 11, 2011·Learning & Behavior·Matthew G WisniewskiEduardo Mercado
Apr 11, 2012·The European Journal of Neuroscience·G Elliott WimmerDaphna Shohamy
Jul 11, 2012·Psychological Review·Dharshan Kumaran, James L McClelland
Oct 16, 2012·Science·G Elliott Wimmer, Daphna Shohamy
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hyunjung LeeMinWhan Jung
Nov 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thorsten KahntPhilippe N Tobler
Jun 12, 2013·Social Cognitive and Affective Neuroscience·Shmuel LissekChristian Grillon
Sep 5, 2013·Biological Psychiatry·Shmuel LissekChristian Grillon
Oct 20, 2014·Nature Neuroscience·Colin G McNamaraDavid Dupret

❮ Previous
Next ❯

Citations

Nov 25, 2017·Nature Communications·Shiva FarashahiAlireza Soltani
Sep 10, 2020·PLoS Computational Biology·Charley M WuNicolas W Schuck
Feb 26, 2019·Behavior Research Methods·Darya FrankDaniela Montaldi
Jan 31, 2019·Frontiers in Behavioral Neuroscience·Arun AsokJoseph B Rayman
Nov 1, 2017·Nature Human Behaviour·Alexander SoutschekPhilippe N Tobler
Dec 17, 2020·Journal of Cognitive Neuroscience·Ewa A MiendlarzewskaSophie Schwartz
Feb 2, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Lauri TuominenDaphne J Holt
Dec 11, 2020·Scientific Reports·Anna LiashenkoCaspar M Schwiedrzik
Jan 9, 2021·Translational Psychiatry·Chao Ciu-Gwok GuoJudith Homberg
Jan 5, 2021·Pain·Lea KampermannChristian Büchel
May 31, 2021·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Aakash A DaveKatharine N Thakkar
Aug 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaux M KenwoodHelen Barbas

❮ Previous
Next ❯

Software Mentioned

SPM12

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Thorsten KahntPhilippe N Tobler
The European Journal of Neuroscience
G Elliott WimmerDaphna Shohamy
© 2021 Meta ULC. All rights reserved