PMID: 9165346May 1, 1997Paper

Dopamine regulates the glutamatergic inner hair cell activity in guinea pigs

Hearing Research
E OestreicherD Felix

Abstract

Recent immunocytochemical and biochemical studies support a possible neurotransmitter function of dopamine (DA) in the efferent olivocochlear innervation of the guinea pig cochlea. However, the physiological role of DA in cochlear neurotransmission remains unknown. In the present study microiontophoretic techniques were used for testing the action of DA as well as D1- and D2-agonists and -antagonists on spontaneous and N-methyl-D-aspartic acid (NMDA)-, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-, kainic acid- or glutamate-induced firing of afferent fibres in the dendritic region of inner hair cells. Subsynaptic spike activities of anaesthetised guinea pigs were recorded after exposing the third or fourth turn of the cochlea for electrode penetration. Application of DA alone had very little effect on the spontaneous afferent firing rate. In contrast, firing induced by NMDA or AMPA could be depressed by additional administration of DA in a dose-dependent manner. A similar reduction of the induced spike activity was seen after co-administration of D1- or D2-agonists. The action of DA on glutamate agonist-induced firing could be blocked by D1- as well as D2-antagonists. These results show that DA can depress th...Continue Reading

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Citations

Oct 19, 2007·HNO·B MazurekA Szczepek
Jun 15, 2006·The Journal of Membrane Biology·G D HousleyE N Yamoah
Aug 29, 2003·Journal of the Association for Research in Otolaryngology : JARO·Colleen G Le PrellSanford C Bledsoe
Mar 1, 2005·Journal of the Association for Research in Otolaryngology : JARO·Colleen G Le PrellSanford C Bledsoe
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Feb 11, 2014·Neuroscience·G PolonyT Zelles
May 13, 1999·Acta Oto-laryngologica·E OestreicherD Felix
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Apr 5, 2018·Frontiers in Neuroanatomy·Melanie Haehnel-TaguchiWolfgang Driever
Jun 18, 2019·Current Biology : CB·Jonathan T PerelmuterPaul M Forlano

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