PMID: 8956010Oct 1, 1996Paper

Dopamine regulation of neurite outgrowth from identified Lymnaea neurons in culture

Cellular and Molecular Neurobiology
G E SpencerN I Syed

Abstract

1. An identified dopaminergic interneuron (RPeD1) of the snail Lymnaea stagnalis, makes specific synaptic connections with a number of target (VI and VJ) but not non-target (VF and RPB) neurons in vivo. When cultured in vitro with both target and non-target cells, RPeD1 re-establishes synapses with target cells only. 2. To test whether exogenous dopamine exerts effects on the neurite outgrowth of both target and non-target neurons respectively, these cells were cultured in conditioned media (CM) in the presence of dopamine (10(-5) M). The growth of the non-target cells was severely restricted and retarded in the presence of dopamine. These data suggest that dopamine may regulate neurite outgrowth of non-target cells in culture. 3. The growth regulatory effects of dopamine on the non-target cells were blocked in the presence of a dopamine receptor antagonist (R(+) SCH-23390, 10(-4) M). These results indicate that dopamine-induced growth regulation of the non-target cells is mediated via dopamine receptors on these cells. 4. In the absence of conditioned media, dopamine was not sufficient to exert growth promoting effects on either target or non-target cells. 5. Taken together, our data show that dopamine differentially regulates...Continue Reading

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Citations

Jun 22, 2000·Microscopy Research and Technique·S B Moffett
Aug 3, 2000·Journal of Anatomy·G W ArbuthnottJ R Wickens
Sep 1, 2011·Thyroid : Official Journal of the American Thyroid Association·Rebecca E Schweppe, Bryan R Haugen
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Dec 11, 2013·Molecular and Cellular Neurosciences·Rainbo HultmanPatrick J Casey
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Feb 19, 2008·The European Journal of Neuroscience·Kwokyin Hui, Zhong-Ping Feng
Aug 7, 1998·Neuroreport·F McCulloch, L Breckenridge
May 14, 2005·The Journal of Comparative Neurology·Gregg D StanwoodPat Levitt
Oct 24, 2020·Cellular and Molecular Neurobiology·Sarah E WalkerGaynor E Spencer
Apr 22, 2006·Developmental Biology·Jennifer M DmetrichukGaynor E Spencer
Nov 4, 2020·Environmental Science & Technology·William Andrew Thompson, Mathilakath M Vijayan

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