PMID: 2496199May 1, 1989Paper

Dopamine release in rat striatum: physiological coupling to tyrosine supply

Journal of Neurochemistry
M J DuringR J Wurtman

Abstract

Intracerebral microdialysis was used to monitor dopamine release in rat striatal extracellular fluid following the intraperitoneal administration of dopamine's precursor amino acid, L-tyrosine. Dopamine concentrations in dialysates increased transiently after tyrosine (50-100 mg/kg) administration. Pretreatment with haloperidol or the partial lesioning of nigrostriatal neurons enhanced the effect of tyrosine on dopamine release, and haloperidol also prolonged this effect. These data suggest that nigrostriatal dopaminergic neurons are responsive to changes in precursor availability under basal conditions, but that receptor-mediated feedback mechanisms limit the magnitude and duration of this effect.

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Citations

Jan 1, 1995·Nutrition Research Reviews·H Kaur, S P Arora
Nov 10, 2011·Brain : a Journal of Neurology·Mai-Anh T NguyenEdna C Hardeman
Apr 30, 2009·Annual Review of Nutrition·Richard J WurtmanIsmail H Ulus
Apr 11, 2008·Brain Research·George E JaskiwRodolfo Bongiovanni
Jan 12, 2005·Physiology & Behavior·Harris R LiebermanSylva K Yeghiayan
Mar 13, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dmitriy MatveychukGlen B Baker
Jan 7, 2014·Medicine and Science in Sports and Exercise·Les TumiltyRhys Thatcher
Mar 7, 2020·Journal of Psychopharmacology·Stefan AhrensChristiane M Thiel
Dec 14, 2019·Medicine and Science in Sports and Exercise·Les TumiltyRhys Thatcher
Feb 1, 1994·Neurochemical Research·S M FarooquiC Prasad
May 22, 2007·The Journal of Nutrition·John D Fernstrom, Madelyn H Fernstrom
Oct 17, 2002·Journal of Applied Physiology·Troy D ChinevereAllen C Parcell
Aug 9, 2017·Oxidative Medicine and Cellular Longevity·Dhaval Patel, Stephan N Witt

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