Dopamine-sensitive adenylate cyclase in homogenates of rat nucleus accumbens: structure-activity studies and effects of agonists and antagonists

European Journal of Pharmacology
K J WatlingJ A Poat

Abstract

A study has been made of the structural requirements for activity on the dopamine-sensitive adenylate cyclase present in homogenates of rat nucleus accumbens. The only active phenylethylamine derivatives tested were those containing hydroxy groups at the 3 and 4 positions on the benzene ring, a two carbon side chain and a terminal nitrogen, either unsubstituted or containing a single methyl group. The alpha- and beta-adrenergic agonists, phenylephrine and isoprenaline respectively, were both inactive. Norsalsolinol was a weak agonist producing only a 50% stimulation of adenylate cyclase activity. The typical neuroleptic drugs, fluphenazine and cis-flupenthixol were both potent antagonists of the dopamine response as opposed to the atypical neuroleptics, metoclopramide and sulpiride, and the alpha- and beta-adrenergic blocking agents, phentolamine and propranolol respectively, which were all inactive. Our results indicate that the dopamine receptors associated with adenylate cyclase in the nucleus accumbens are similar to those in the corpus striatum.

References

Jun 13, 1975·Science·L Iversen
Jul 1, 1977·The Journal of Pharmacy and Pharmacology·G N WoodruffJ D McDermed
Aug 1, 1978·The Journal of Pharmacy and Pharmacology·J A PoatK J Watling
May 1, 1977·Neuropharmacology·P N ElliottR Miller
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·Y C Clement-CormierP Greengard
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Sep 1, 1967·The Journal of Pharmacy and Pharmacology·N E AndénT Hökfelt
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J W KebabianP Greengard

Citations

Dec 23, 1983·European Journal of Pharmacology·R D Pinnock
Jul 1, 1980·Pharmacology, Biochemistry, and Behavior·M R Dzoljic, A L van der Poel-Heisterkamp
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·J N Joyce
Jul 1, 1980·The Journal of Pharmacy and Pharmacology·A S Horn, J R Rodgers
Jun 21, 2017·Chemistry : a European Journal·Akira MizunoSatoshi Shuto

Related Concepts

Adenylate Cyclase
Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Metazoa
Apokinon
Intropin
Fluanxol
Lyogen
Nucleus Accumbens
Phenethylamines

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.