Dopamine signaling in the medial prefrontal cortex and amygdala is required for the acquisition of fructose-conditioned flavor preferences in rats.

Behavioural Brain Research
Danielle C MalkuszRichard J Bodnar

Abstract

Systemic administration of dopamine (DA) D1 (SCH23390: SCH) and D2 (raclopride: RAC) antagonists blocked both acquisition and expression of fructose-conditioned flavor preferences (CFP). It is unclear what brain circuits are involved in mediating these effects. The present study investigated DA signaling within the nucleus accumbens shell (NAcS), amygdala (AMY) and medial prefrontal cortex (mPFC) in the acquisition and expression of fructose-CFP. In Experiment 1, separate groups of rats were injected daily in the NAcS or AMY with saline, SCH (24 nmol) or RAC (24 nmol) prior to training sessions with a flavor (CS+) mixed with 8% fructose and 0.2% saccharin (CS+/F) and a different flavor (CS-) mixed with only 0.2% saccharin. In the two-bottle choice tests with 0.2% saccharin, only rats injected with RAC in the AMY failed to acquire a CS+ preference (45-54%). In Experiment 2, new rats were identically trained, but saline, SCH and RAC were injected in the mPFC. In subsequent two-bottle choice tests, SCH- and RAC-treated rats failed to exhibit a CS+ preference (50-56%). In Experiment 3, new rats were trained with CS+/F and CS- without injections. Subsequent two-bottle choice tests were then conducted following bilateral injections o...Continue Reading

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Citations

Sep 17, 2014·Pharmacology, Biochemistry, and Behavior·Severiano Risco, Cristina Mediavilla
Oct 30, 2012·Neurobiology of Learning and Memory·J A D Dela CruzR J Bodnar
Oct 26, 2016·Pharmacology, Biochemistry, and Behavior·Francis M RotellaRichard J Bodnar
Sep 15, 2016·Scientific Reports·Cristina MediavillaSeveriano Risco
Jan 18, 2013·Journal of Psychopharmacology·Holly C MillerJustine Blampain
Feb 28, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Richard MattaElena Choleris
Jun 29, 2021·Neuroscience and Biobehavioral Reviews·Mikayla A Payant, Melissa J Chee
Jul 7, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Juliana L GiacominiBrian A Baldo

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