Dopamine spillover after quantal release: rethinking dopamine transmission in the nigrostriatal pathway.

Brain Research Reviews
M E Rice, Stephanie J Cragg

Abstract

The predominance of dopamine (DA) receptors at extrasynaptic vs. synaptic sites implies that DA signaling is by diffusion-based volume transmission. In this review, we compare characteristics that regulate extracellular DA behavior in substantia nigra pars compacta (SNc) and striatum, including regional differences in structure (a 40% greater extracellular volume fraction in SNc vs. striatum) and in dynamic DA uptake (a 200-fold greater DA uptake rate in striatum vs. SNc). Furthermore, we test the assumption of diffusion-based volume transmission for SNc and striatum by modeling dynamic DA behavior after quantal release using region-specific parameters for diffusion and uptake at 37 degrees C. Our model shows that DA uptake does not affect peak DA concentration within 1 mum of a release site in either SNc or striatum because of the slow kinetics of DATs vs. diffusion. Rather, diffusion and dilution are the dominant factors governing DA concentration after quantal release. In SNc, limited DAT efficacy is reflected in a lack of influence of uptake on either amplitude or time course of DA transients after quantal release up to 10 mum from a release site. In striatum, the lack of effect of the DAT within 1 mum of a release site mea...Continue Reading

References

Nov 24, 1977·Experimental Brain Research·C J WilsonE Fifková
May 1, 1995·Neuron·J I WadicheM P Kavanaugh
Nov 25, 1993·Nature·D L Cameron, J T Williams
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P WitkovskyE Meller
Feb 17, 1998·The European Journal of Neuroscience·O P Ottersen, A S Landsend
Jun 4, 1998·Trends in Neurosciences·C Nicholson, E Syková
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z U KhanP S Goldman-Rakic
May 20, 1999·Annual Review of Pharmacology and Toxicology·R P Seal, S G Amara
Aug 11, 1999·Trends in Neurosciences·D A RusakovM G Stewart
Mar 16, 2000·Reviews in the Neurosciences·D Sulzer, E N Pothos
May 23, 2001·Progress in Neurobiology·N C Danbolt
Sep 29, 2001·Science·B H FalkenburgerI M Mintz
Feb 14, 2002·Synapse·Paul E M PhillipsJonathan A Stamford
Apr 28, 2004·Trends in Neurosciences·Stephanie J Cragg, Margaret E Rice
Dec 19, 2006·Trends in Neurosciences·Gordon W Arbuthnott, Jeff Wickens
Sep 8, 2007·The European Journal of Neuroscience·Michael J BecksteadJohn T Williams

❮ Previous
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Citations

Feb 15, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Georges VauquelinPhilip Seeman
Aug 27, 2010·Acta Neuropathologica·Alipi V NaydenovChristine Konradi
Sep 12, 2013·Cell and Tissue Research·Elmira Anderzhanova, Carsten T Wotjak
May 16, 2013·Chinese Journal of Integrative Medicine·Kjell FuxeLuigi F Agnati
Apr 23, 2013·ACS Chemical Neuroscience·I Mitch TaylorAdrian C Michael
Mar 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Luca FerraroKjell Fuxe
Apr 21, 2009·Nature Reviews. Neuroscience·Martin SarterW Matthew Howe
Apr 15, 2010·Nature Reviews. Neuroscience·Christian Lüscher, Paul A Slesinger
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Robert M SearsJoseph E Ledoux
Oct 27, 2011·The Journal of Biological Chemistry·Hirofumi TokuokaHiroshi Ichinose
Mar 28, 2012·The Journal of Biological Chemistry·Simon BullingWalter Sandtner
Jan 14, 2011·The Journal of Pharmacology and Experimental Therapeutics·Michael H BaumannRichard B Rothman
May 4, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ji Hyun Ko, Antonio P Strafella
Feb 22, 2012·PLoS Computational Biology·Rodrigo F OliveiraKim T Blackwell
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher P FordJohn T Williams
Aug 30, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yen YuKarl J Friston
Jul 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li BaoMargaret E Rice
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ryan M DrenanHenry A Lester
Oct 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher P FordJohn T Williams
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ledia F HernandezAnn M Graybiel
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fu-Wen ZhouFu-Ming Zhou
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca E HortonLynette C Daws
May 26, 2011·Neurochemical Research·Gonzalo FloresLeonardo Rodríguez-Sosa
Jul 16, 2013·Brain Structure & Function·Mats Julius StensrudVidar Gundersen
Oct 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yvonne SchmitzDavid Sulzer
Feb 18, 2016·ACS Chemical Neuroscience·Seth H WaltersAdrian C Michael
Jan 31, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Veronica BisagnoFrancisco J Urbano
Jan 16, 2016·The Journal of Pharmacology and Experimental Therapeutics·Weimin C HongJonathan L Katz
May 4, 2016·Basal Ganglia·David SulzerMargaret E Rice
Sep 11, 2012·Neuropharmacology·Ingrid MoralesManuel Rodriguez
May 12, 2012·Brain Research·Rehana K Leak, Robert Y Moore
Apr 21, 2012·Brain Research·Elizabeth Palomares-CastilloMiguel Pérez de la Mora
Oct 25, 2011·Trends in Neurosciences·Ned Jenkinson, Peter Brown
Sep 24, 2011·Neuroscience·M E RiceS J Cragg
Mar 30, 2010·Brain Research Reviews·Luigi F AgnatiKjell Fuxe
Oct 27, 2009·Progress in Neurobiology·Ingrid StrömbergGreg A Gerhardt

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