PMID: 3773646Nov 17, 1986Paper

Dopamine-stimulated adenylate cyclase in human term placenta

Life Sciences
F Ferre

Abstract

The effect of dopamine on adenylate cyclase activity was investigated in slices of human term placentas. Dopamine elicited a dose-dependent stimulation of cAMP formation with a ED50 value of about 1 X 10(-6)M dopamine and an increase of 110% over the control with 1 X 10(-4)M dopamine. (-)-Epinephrine and (-)-norepinephrine also increased placental cAMP formation. Apomorphine displayed a slight but non-significant stimulatory effect while bromocriptine was not effective. SCH 23390, a selective antagonist of dopamine D1 receptors caused a dose-dependent decrease of the dopamine activation. In contrast, the dopamine increase of cAMP was unaffected by beta- and alpha-adrenergic blocking drugs and by the D2 selective antagonist, (-)-sulpiride. These data indicate that dopamine stimulates cAMP formation in human term placenta through a specific mechanism via D1 dopaminergic receptors positively coupled to adenylate cyclase.

References

Jul 1, 1978·The Journal of Clinical Endocrinology and Metabolism·C MacaronS P Singh
Nov 1, 1979·The Journal of Clinical Endocrinology and Metabolism·A GolanderS Handwerger
Aug 1, 1975·Journal of Neurochemistry·Y C Clement-CormierP Greengard
Mar 26, 1985·European Journal of Pharmacology·A Dumbrille-RossP Seeman
May 1, 1983·The Journal of Clinical Endocrinology and Metabolism·S N CaritisA J Zeleznik
Dec 3, 1984·Life Sciences·J C Stoof, J W Kebabian
Apr 1, 1982·Placenta·L MilewichP C MacDonald
Nov 1, 1980·The Journal of Clinical Endocrinology and Metabolism·N Ben-Jonathan, R A Munsick

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Citations

Nov 1, 1987·Molecular and Cellular Endocrinology·H B Niznik
Oct 1, 1994·Journal of Autonomic Pharmacology·J A de AlmeidaF Amenta
Mar 1, 1992·Placenta·M M JacobsN P Illsley
Sep 1, 1992·Placenta·J F StraussM E Gåfvels
Mar 1, 1997·Placenta·T YanagawaT Kudo
Jan 1, 1990·Journal of Receptor Research·A PetitS Bélisle
Nov 1, 1987·Placenta·R L Ingermann

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