Dopamine stimulation of cardiac beta-adrenoceptors: the involvement of sympathetic amine transporters and the effect of SKF38393

British Journal of Pharmacology
Y HabuchiM Yoshimura

Abstract

1. Mechanisms underlying beta-adrenoceptor stimulation by dopamine were examined on guinea-pig Langendorff-perfused hearts and isolated cells from the right atrium, by using the chronotropic effects and the enhancement of L-type Ca2+ current (ICa,L) in the presence of prazosin as indicators of beta-adrenoceptor stimulation. Dopamine-induced overflow of noradrenaline (NA) concentrations was measured by high-performance liquid chromatography. 2. Dopamine caused positive chronotropic effects with an EC50 of 2.5 microM and induced NA overflow with a similar EC50 (1.3 microM). The chronotropic effect of dopamine was abolished by bisoprolol (1 microM). 3. The effects of dopamine were maintained during prolonged application, whereas the effects of tyramine faded with time. Dopamine (3 microM) restored the chronotropic effects and the NA release suppressed by pretreatment with tyramine, suggesting a de novo synthesis of NA during the exposure to dopamine. 4. Dopamine (3 microM)-induced NA release was not affected by tetrodotoxin, omega-conotoxin, rauwolscine, ICI118551 or sulpiride, but was inhibited by desipramine, a NA uptake inhibitor (IC50 approximately 1 microM). It was also not affected by GBR12909 and bupropion, dopamine uptake ...Continue Reading

References

Feb 15, 1977·Biochemical Pharmacology·K StarkeE Browski
Jan 11, 1979·Nature·J W Kebabian, D B Calne
Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·A MugelliT Maccioni
Jul 1, 1992·Pflügers Archiv : European journal of physiology·M BoutjdirN el-Sherif
Sep 1, 1991·British Journal of Pharmacology·L J Van WoerkensP D Verdouw
Oct 1, 1990·British Journal of Pharmacology·A De LucaH K Wong-Dusting
Aug 1, 1988·The Journal of General Physiology·R Horn, A Marty
Aug 3, 1989·European Journal of Pharmacology·P H Andersen
Jul 4, 1989·European Journal of Pharmacology·T W LovenbergR B Mailman
Jun 1, 1987·Journal of Autonomic Pharmacology·I Martinez-MirE Rubio
Jan 1, 1987·Blood Vessels·U TrendelenburgH Bönisch
Feb 1, 1971·British Journal of Pharmacology·G HellmannB Peskar
Sep 1, 1980·Journal of Cardiovascular Pharmacology·O E BroddeH J Schümann
Jul 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·H Bönisch, E Rodrigues-Pereira
Sep 1, 1982·Journal of Autonomic Pharmacology·M F Lokhandwala, R J Barrett
Aug 1, 1981·Acta Anaesthesiologica Scandinavica·P O JärnbergB Hamberger
Apr 4, 1995·European Journal of Pharmacology·T VegaA G García
Feb 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·F AmentaA Ricci
Jun 1, 1995·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Y HabuchiM Yoshimura
Sep 1, 1995·Journal of Cardiovascular Pharmacology·L C RumpP Schollmeyer
Mar 1, 1996·Hypertension·R OzonoR M Carey

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Citations

Dec 5, 2013·Physiological Reports·Josh S TitlowRobin L Cooper
Jun 18, 2004·Seminars in Perinatology·John Edward Jones, Pedro A Jose
Nov 14, 2006·British Journal of Pharmacology·J T LilesP J Kadowitz
May 3, 2007·The Journal of Physiological Sciences : JPS·Yoshiakira Wakita
Feb 24, 2006·Anesthesia and Analgesia·María Jesús Juan-FitaJesús Hernández
Oct 19, 2013·The Journal of Pharmacology and Experimental Therapeutics·Christiane VettelBenito A Yard
Sep 14, 2012·Journal of Biomolecular Screening·Oksana SirenkoEvan F Cromwell
Feb 17, 2021·Translational Psychiatry·Despoina AslanoglouZachary Freyberg

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