Dopamine Synthesis as a Mechanism of Brain Plasticity in Nigrostriatal System Pathology

Doklady. Biochemistry and Biophysics
A A Kolacheva, M V Ugrumov

Abstract

Using an experimental Parkinson's disease model (symptoms develop in mice after the injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), we studied the characteristics of the synthesis of dopamine as a possible compensatory mechanism aimed at maintaining the dopamine level in the dopaminergic neurons that survived in this pathology. We found no correlation between the content and activity of tyrosine hydroxylase in the nigrostriatal system. The enzyme activity and the dopamine content showed unidirectional changes in the substantia nigra, but not in the striatum, which is apparently due to triggering other compensatory mechanisms.

References

Jun 1, 1991·Lancet·Y Agid
Jan 1, 1973·Journal of Neural Transmission·A Carlsson, M Lindqvist
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·J AraH Ischiropoulos
Jan 22, 2003·The European Journal of Neuroscience·Kati KühnChristine C Stichel
Feb 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Francesco FornaiThomas C Südhof
Feb 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·G MorfiniS T Brady
Apr 3, 2007·Nature Protocols·Vernice Jackson-Lewis, Serge Przedborski
Mar 9, 2011·Neuroscience·M V UgrumovT S Pronina

❮ Previous
Next ❯

Citations

Aug 15, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Saad LatifMohammad Azam Ansari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.