Dopamine Transporter, Age, and Motor Complications in Parkinson's Disease: A Clinical and Single-Photon Emission Computed Tomography Study.

Movement Disorders : Official Journal of the Movement Disorder Society
Giovanni PalermoRoberto Ceravolo

Abstract

Previous molecular imaging studies comparing dopamine function in vivo between early-onset PD and late-onset PD patients have shown contradictory results, presumably attributable to the aging-related decline in nigrostriatal function. (1) To investigate baseline dopamine transporter availability in early-onset PD (<55 years) and late-onset PD (>70 years) patients, z-scores values of putamen and caudate [123 I]-ioflupane uptake were calculated using the respective age-matched controls in order to correct for early presynaptic compensatory mechanisms and age-related dopamine neuron loss; (2) to examine the associations of such baseline single-photon emission computed tomography measures with the emergence of late-disease motor complications. In this retrospective study, 105 de novo PD patients who underwent [123 I]-ioflupane single-photon emission computed tomography at time of diagnosis were divided into three tertile groups according to age at disease onset (35 early-onset PD and 40 late-onset PD patients). Z-scores were compared between the two groups, and their predictive power for motor complications (during a mean follow-up of 7 years) was evaluated using Cox proportional hazard models. Despite a less-severe motor phenotype...Continue Reading

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Oct 9, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·I P AlonsoR A España
Jun 15, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Eleonora FiorenzatoRoberta Biundo
Sep 9, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Audrey MailletStéphane Thobois

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