Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease

Parkinsonism & Related Disorders
Jared T HinkleGregory M Pontone

Abstract

Constipation is a prodromal feature of Parkinson's disease (PD) and the gastrointestinal (GI) tract is implicated in the pathogenesis of PD. However, no studies have demonstrated ante-mortem relationships between nigrostriatal dysfunction and GI dysautonomia in PD. The Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT) assesses dysautonomia in the multi-center Parkinson's Progression Marker Initiative (PPMI). We used linear mixed-effects models and reliable change indices (RCIs) to examine longitudinal associations between dysautonomia and dopamine transporter (DAT) striatal binding ratios (SBRs) measured by single-photon emission computerized tomography in PPMI participants over four years (n = 397 at baseline). Adjusted mixed-models of longitudinal data showed that constipation-but not orthostatic hypotension or urinary dysfunction-was associated with reduced SBR in both caudate (P < 0.001) and putamen (P = 0.040). In both regions, SBR reductions between baseline and 4-year follow-up were significant and measurable (P < 0.0001), with larger decline and variance in the caudate nucleus. Four-year change in caudate-but not putaminal-SBR was significantly associated with RCI-indicated progression of GI d...Continue Reading

Citations

Mar 13, 2020·Journal of Neurology·Dagmar N van DeursenChris Vriend
May 8, 2020·Brain : a Journal of Neurology·Marie-Laure ArotcarenaErwan Bezard
Feb 11, 2020·Expert Opinion on Pharmacotherapy·Shilan MozaffariMohammad Abdollahi
Jan 4, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jeanette M Metzger, Marina E Emborg
May 18, 2020·BMC Neurology·Nicolas NicastroPierre R Burkhard
Nov 29, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Kathryn A Chung, Ronald F Pfeiffer
Feb 14, 2021·Journal of Parkinson's Disease·Amir Ashraf-GanjoueiZahra Vahabi
Feb 16, 2021·The Journal of Clinical Investigation·Michael Camilleri
May 28, 2021·NPJ Parkinson's Disease·M CamachoC H Williams-Gray
Jun 10, 2021·Medicinal Research Reviews·Ramón CacabelosJuan C Carril
Jul 3, 2021·Brain Sciences·Heithem SolimanGuillaume Gourcerol
Sep 25, 2021·Journal of Neural Transmission·Tomomichi KitagawaYasuyuki Iguchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Hisayoshi OkaS Mochio
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Daniel WeintraubIra R Katz
Movement Disorders : Official Journal of the Movement Disorder Society
Françoise J SiepelDag Aarsland
© 2022 Meta ULC. All rights reserved