Dopamine transporter is essential for the maintenance of spontaneous activity of auditory nerve neurones and their responsiveness to sound stimulation

Journal of Neurochemistry
J RuelG Rebillard

Abstract

Dopamine, a neurotransmitter released by the lateral olivocochlear efferents, has been shown tonically to inhibit the spontaneous and sound-evoked activity of auditory nerve fibres. This permanent inhibition probably requires the presence of an efficient transporter to remove dopamine from the synaptic cleft. Here, we report that the dopamine transporter is located in the lateral efferent fibres both below the inner hair cells and in the inner spiral bundle. Perilymphatic perfusion of the dopamine transporter inhibitors nomifensine and N-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine into the cochlea reduced the spontaneous neural noise and the sound-evoked compound action potential of the auditory nerve in a dose-dependent manner, leading to both neural responses being completely abolished. We observed no significant change in cochlear responses generated by sensory hair cells (cochlear microphonic, summating potential, distortion products otoacoustic emissions) or in the endocochlear potential reflecting the functional state of the stria vascularis. This is consistent with a selective action of dopamine transporter inhibitors on auditory nerve activity. Capillary electrophoresis with laser-induced fluorescence (EC-LIF) measur...Continue Reading

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Citations

Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stéphane F MaisonM Charles Liberman
Nov 16, 2007·The European Journal of Neuroscience·S LadrechM Lenoir
May 9, 2014·Acta Oto-laryngologica·Lin WangXingqi Li
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Mar 27, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Evelien De GrooteMiet De Letter
Jun 11, 2021·Hearing Research·Siân R KitcherCatherine J C Weisz

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