Dopamine transporter regulates the enhancement of novelty processing by a negative emotional context

Neuropsychologia
M Garcia-GarciaCarles Escera

Abstract

The dopaminergic (DA) system has been recently related the emotional modulation of cognitive processes. Moreover, patients with midbrain DA depletion, such as Parkinson's Disease (PD), have shown diminished reactivity during unpleasant events. Here, we examined the role of DA in the enhancement of novelty processing during negative emotion. Forty healthy volunteers were genotyped for the dopamine transporter (DAT) gene SLC6A3 or DAT1 and performed an auditory-visual distraction paradigm in negative and neutral emotional context conditions. 9R- individuals, associated to a lesser striatal DA display, failed to show increased distraction during negative emotion, but experienced an enhancement of the early phase of the novelty-P3 brain response, associated to the evaluation of novel events, in the negative relative to the neutral context. However, 9R+ individuals (associated to larger striatal DA display) showed larger distraction during negative emotion and larger amplitudes of the novelty-P3, irrespective of the condition. These results suggest a blunted reactivity to novelty during negative emotion in 9R- individuals due to a lesser DA display and stronger activation of the representation of novel events in the 9R+ group, due t...Continue Reading

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Citations

Aug 24, 2013·Psychiatry·Chieh-Hsin LinHsien-Yuan Lane
Aug 6, 2014·Translational Psychiatry·O BergmanE Eriksson
Feb 5, 2016·Brain Imaging and Behavior·Brenna K BrownAmit Anand
Jan 4, 2012·Biological Psychology·Judith Domínguez-BorràsCarles Escera
Sep 8, 2011·Depression and Anxiety·Moritz IschebeckNorbert Kathmann
Mar 9, 2012·Brain and Behavior·Andrea FeltenMartin Reuter
Aug 2, 2012·Experimental Psychology·Leigh M Riby
May 2, 2014·Research in Developmental Disabilities·Kenneth D GadowWolfgang Sadee
Oct 12, 2010·Neuropsychologia·M Garcia-GarciaC Escera
Nov 26, 2015·Journal of Psychopharmacology·Mauricio Rangel-Gomez, Martijn Meeter
Jan 1, 2014·Borderline Personality Disorder and Emotion Dysregulation·Thomas DreslerAndreas J Fallgatter

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