PMID: 9443655Jan 27, 1998Paper

Dopamine uptake sites, labelled with [3H]GBR12935, in brain samples from depressed suicides and controls

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
C BowdenR W Horton

Abstract

We have quantitated dopamine uptake sites, labelled with [3H]GBR12935, in caudate, putamen and nucleus accumbens of suicides with a retrospective diagnosis of depression, and age and gender-matched controls. Suicides were subdivided into those who had been free of antidepressant drugs for at least three months, and those in whom prescription of antidepressant drugs was clearly documented. We found no significant differences between controls and suicides overall, or when the suicides were divided on the basis of antidepressant treatment or violence of death. A significant negative correlation between the number of dopamine uptake sites and age was found in each region studied. Our results suggest dopamine uptake sites are not critically involved in depression or antidepressant drug action.

References

Sep 1, 1979·Journal of Affective Disorders·L ColonnaJ P Lepine
Jan 1, 1977·British Journal of Clinical Pharmacology·J D Van ScheyenJ Korf
May 8, 1976·British Medical Journal·J P YoungM H Lader
Oct 1, 1976·Archives of General Psychiatry·M AsbergP Thorén
Jan 1, 1992·Pharmacology & Toxicology·F De PaermentierR W Horton
Jan 1, 1990·European Neurology·R K PearceW W Tourtellotte
Nov 1, 1989·Neurobiology of Aging·P Allard, J O Marcusson
Jan 1, 1989·Journal of Neural Transmission·C Czudek, G P Reynolds
Aug 2, 1988·Brain Research·J Marcusson, K Eriksson
Mar 8, 1988·Brain Research·S C CheethamR W Horton
Jul 15, 1986·European Journal of Pharmacology·N ZelnikJ E Kleinman
Jan 1, 1973·The American Journal of Psychiatry·F K GoodwinE K Gordon
May 1, 1969·International Journal of Neuropharmacology·M B BowersF Gerbode
Jul 1, 1981·Acta Psychiatrica Scandinavica·C NordinL Bertilsson
Feb 1, 1980·The American Journal of Psychiatry·P A BergerJ D Barchas
Jan 1, 1994·Journal of Neurochemistry·P AllardJ O Marcusson
Jan 1, 1992·Journal of Psychopharmacology·A AnderssonJ Marcusson

❮ Previous
Next ❯

Citations

Jan 18, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·George I Papakostas
Apr 22, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Erkki TupalaJari Tiihonen
Sep 3, 2014·Molecular Psychiatry·M SokolowskiD Wasserman
Jul 13, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Megan L FitzgeraldVictoria Arango

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.