PMID: 9537683Apr 16, 1998Paper

Dopaminergic activity and the discriminative stimulus effects of mu opioids in pigeons: importance of training dose and attenuation by the D3 agonist (+/-)-7-OH-DPAT

Psychopharmacology
C D Cook, M J Picker

Abstract

The present investigation examined the effects of several dopaminergic compounds in pigeons trained to discriminate either a 0.1 (low) or 5.6 (high) mg/kg dose of the mu opioid butorphanol from saline. Various dopamine (DA) re-uptake inhibitors, releasers, a D1 agonist, a D2 agonist and a D3 agonist engendered partial substitution (50-79% butorphanol responding) for the butorphanol stimulus in the low-dose group. In the high-dose group, with a few exceptions, these compounds produced predominately saline responding. In the low-dose group, the opioid antagonist naloxone antagonized the stimulus effects produced by butorphanol, but failed to attenuate the butorphanol-like discriminative stimulus effects produced by the DA re-uptake inhibitors mazindol and cocaine. The D1 antagonist (+)-SCH 23390 and the D2 antagonist raclopride failed to attenuate the stimulus effects produced by either the low or high training dose of butorphanol. Doses of mazindol and cocaine that engendered between 16% and 70% butorphanol responding failed to alter the butorphanol dose-effect curve in either the low- or high-dose group, indicating a less than additive interaction. In the high-dose group, the D3 agonist (+/-)-7-hydroxy-dipropylaminotetralin [(+...Continue Reading

Citations

Feb 21, 2004·Journal of Neuroimmunology·Timothy B SaurerDonald T Lysle
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Charles D Cook, Patrick M Beardsley
Mar 26, 2003·Brain Research. Molecular Brain Research·Rudolph SpanglerSarah F Leibowitz
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Sep 14, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·G AtalanM Cenesiz
Dec 8, 2009·The Journal of Pharmacology and Experimental Therapeutics·Donna M PlattRoger D Spealman
May 15, 2015·Journal of Pharmacological and Toxicological Methods·David V GauvinTheodore J Baird
Feb 27, 2004·The Journal of Pharmacology and Experimental Therapeutics·James K RowlettRoger D Spealman

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