Dopaminergic and alpha-adrenergic control of neurotransmission in human right atrium

Journal of Cardiovascular Pharmacology
L C RumpP Schollmeyer

Abstract

The aim of the present study was to investigate dopamine receptor- and alpha-adrenergic receptor-mediated modulation of norepinephrine release in human atria. Right atrial appendages were incubated with 3H-norepinephrine, placed in superfusion chambers, and field-stimulated by platinum electrodes at a frequency of 5 Hz. The stimulation-induced (S-I) outflow of radioactivity was taken as an index of norepinephrine release. The dopamine D2-receptor agonist quinpirole (0.03-3 microM) concentration dependently inhibited the S-I outflow of radioactivity with an EC50 of 0.03 microM. The concentration-response curve of quinpirole was potently shifted to the right by the D2-receptor antagonists domperidone (0.003 microM, pKB approximately 9.2) and S(-)-sulpiride (0.1 microM, pKB approximately 8.6). The D1-receptor antagonist SCH 23390 (1 microM) slightly (pKB approximately 6.9) shifted the concentration-response curve of quinpirole, whereas the alpha 2-adrenergic antagonist rauwolscine (0.01 microM) and the alpha 1-adrenergic antagonist prazosin (1 microM) had no effect. The D1-receptor agonist did not affect fenoldopam (0.03 and 0.3 microM), but fenoldopam (3 microM) enhanced the S-I outflow of radioactivity. The facilitatory effect o...Continue Reading

Citations

Dec 14, 1996·Journal of the Autonomic Nervous System·C AbadieR Nadeau
Nov 1, 1995·British Journal of Pharmacology·L C RumpN Limberger
Dec 21, 2010·Neurochemical Research·Alejandro Reynoso PalomarMaria de Jesús Gómez-Villalobos
Feb 7, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Wendell S Akers, Lisa A Cassis
Jul 16, 2002·Canadian Journal of Physiology and Pharmacology·Maria de Jesus GómezJorge Suárez
Apr 14, 2006·Journal of Pharmacological Sciences·Otto-Erich BroddeKirsten Leineweber
May 1, 1997·Journal of Cardiovascular Pharmacology·L C RumpP Schollmeyer
Sep 30, 2020·Bulletin of Experimental Biology and Medicine·N I ZiyatdinovaT L Zefirov
Sep 16, 2000·Hypertension·G J MolderingsM Göthert
Dec 2, 2020·Journal of Cardiovascular Development and Disease·Laura Fedele, Thomas Brand

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