PMID: 43880Dec 1, 1979

Dopaminergic control of oxytocin release in lactating rats

The Journal of Endocrinology
G ClarkeL P Merrick

Abstract

During suckling, anaesthetized lactating rats release regular (about every 7 min) but brief pulses of oxytocin (0.5--1.0 mu.) which produce single transient increases in intramammary pressure. Drugs which selectively impair synaptic transmission were used to determine the role of dopamine and noradrenaline in regulating this natural reflex. Diethyldithiocarbamate (100--200 mg/kg, i.v.) and alpha-methylparatyrosine (100--400 mg/kg, i.v.) which inhibit the synthesis of catecholamines both blocked the suckling-induced release of oxytocin. The milk-ejection reflex was also inhibited in a dose-dependent manner by the intravenous administration of the dopamine antagonists, fluphenazine (0.7 mg/kg), pimozide (1.4 mg/kg), cis-dupenthixol (4.5 mg/kg) and metoclopramide (6.0 mg/kg), and caused a significant inhibition P less than 0.01) of the reflex in 50% of the rats tested. The alpha-adrenoceptor antagonist phenoxybenzamine (1.4 mg/kg) was similarly effective. Dopamine (40 micrograms), bromocriptine (10 micrograms), apomorphine (100 micrograms), noradrenaline (10 micrograms) and phenylephrine (2 micrograms) injected into the cerebral ventricles evoked a sustained release of oxytocin which produced multiple increases in intramammary pre...Continue Reading

Citations

Jan 1, 1984·European Archives of Psychiatry and Neurological Sciences·P LinkowskiJ J Legros
Jan 1, 1993·Journal of Neural Transmission. General Section·T SkutellaG F Jirkowski
May 5, 1994·Regulatory Peptides·P ChioderaV Coiro
Apr 1, 1994·Brain Research. Molecular Brain Research·T SkutellaG F Jirikowski
Apr 10, 1989·Neuroscience Letters·M R MelisG L Gessa
Sep 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Emilia DíazAnita Israel
Jun 12, 1992·Annals of the New York Academy of Sciences·R ArlettiA Bertolini
Jun 8, 2011·International Breastfeeding Journal·Alia M Heise, Diane Wiessinger
Jul 3, 2007·Frontiers in Neuroendocrinology·Joseph S Lonstein
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·C S Carter
Oct 1, 1983·Journal of Dairy Science·G T Goodman, C E GROSVENOR
Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
Jun 12, 1992·Annals of the New York Academy of Sciences·W R CrowleyC E GROSVENOR
Apr 8, 1998·The American Journal of Physiology·S L Bealer, W R Crowley

Related Concepts

Amines
Catecholamines
Intropin
Injections, Intraventricular
Lactation, Prolonged
Udder
Norepinephrine, (+, -)-Isomer
Syntocinon
Secretory Rate
Neurohormones

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