PMID: 43880Dec 1, 1979

Dopaminergic control of oxytocin release in lactating rats

The Journal of Endocrinology
G ClarkeL P Merrick


During suckling, anaesthetized lactating rats release regular (about every 7 min) but brief pulses of oxytocin (0.5--1.0 mu.) which produce single transient increases in intramammary pressure. Drugs which selectively impair synaptic transmission were used to determine the role of dopamine and noradrenaline in regulating this natural reflex. Diethyldithiocarbamate (100--200 mg/kg, i.v.) and alpha-methylparatyrosine (100--400 mg/kg, i.v.) which inhibit the synthesis of catecholamines both blocked the suckling-induced release of oxytocin. The milk-ejection reflex was also inhibited in a dose-dependent manner by the intravenous administration of the dopamine antagonists, fluphenazine (0.7 mg/kg), pimozide (1.4 mg/kg), cis-dupenthixol (4.5 mg/kg) and metoclopramide (6.0 mg/kg), and caused a significant inhibition P less than 0.01) of the reflex in 50% of the rats tested. The alpha-adrenoceptor antagonist phenoxybenzamine (1.4 mg/kg) was similarly effective. Dopamine (40 micrograms), bromocriptine (10 micrograms), apomorphine (100 micrograms), noradrenaline (10 micrograms) and phenylephrine (2 micrograms) injected into the cerebral ventricles evoked a sustained release of oxytocin which produced multiple increases in intramammary pre...Continue Reading


Jan 1, 1984·European Archives of Psychiatry and Neurological Sciences·P LinkowskiJ J Legros
Jan 1, 1993·Journal of Neural Transmission. General Section·T SkutellaG F Jirkowski
May 5, 1994·Regulatory Peptides·P ChioderaV Coiro
Apr 1, 1994·Brain Research. Molecular Brain Research·T SkutellaG F Jirikowski
Apr 10, 1989·Neuroscience Letters·M R MelisG L Gessa
Sep 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Emilia DíazAnita Israel
Jun 12, 1992·Annals of the New York Academy of Sciences·R ArlettiA Bertolini
Jun 8, 2011·International Breastfeeding Journal·Alia M Heise, Diane Wiessinger
Jul 3, 2007·Frontiers in Neuroendocrinology·Joseph S Lonstein
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·C S Carter
Oct 1, 1983·Journal of Dairy Science·G T Goodman, C E GROSVENOR
Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
Jun 12, 1992·Annals of the New York Academy of Sciences·W R CrowleyC E GROSVENOR
Apr 8, 1998·The American Journal of Physiology·S L Bealer, W R Crowley

Related Concepts

Injections, Intraventricular
Lactation, Prolonged
Norepinephrine, (+, -)-Isomer
Secretory Rate

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here