Dopaminergic control of the globus pallidus through activation of D2 receptors and its impact on the electrical activity of subthalamic nucleus and substantia nigra reticulata neurons

PloS One
Omar MamadA Benazzouz

Abstract

The globus pallidus (GP) receives dopaminergic afferents from the pars compacta of substantia nigra and several studies suggested that dopamine exerts its action in the GP through presynaptic D2 receptors (D2Rs). However, the impact of dopamine in GP on the pallido-subthalamic and pallido-nigral neurotransmission is not known. Here, we investigated the role of dopamine, through activation of D2Rs, in the modulation of GP neuronal activity and its impact on the electrical activity of subthalamic nucleus (STN) and substantia nigra reticulata (SNr) neurons. Extracellular recordings combined with local intracerebral microinjection of drugs were done in male Sprague-Dawley rats under urethane anesthesia. We showed that dopamine, when injected locally, increased the firing rate of the majority of neurons in the GP. This increase of the firing rate was mimicked by quinpirole, a D2R agonist, and prevented by sulpiride, a D2R antagonist. In parallel, the injection of dopamine, as well as quinpirole, in the GP reduced the firing rate of majority of STN and SNr neurons. However, neither dopamine nor quinpirole changed the tonic discharge pattern of GP, STN and SNr neurons. Our results are the first to demonstrate that dopamine through act...Continue Reading

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Citations

Feb 22, 2017·Translational Psychiatry·K D ErscheG B Williams
Sep 27, 2019·Stress : the International Journal on the Biology of Stress·Hui QiaoShu-Cheng An
Feb 4, 2016·The European Journal of Neuroscience·Daniel J HegemanC Savio Chan
Mar 13, 2019·Frontiers in Neural Circuits·Vignayanandam Ravindernath MuddapuSrikanth Ramaswamy
Sep 27, 2018·Journal of Neurophysiology·Verónica Alejandra Cáceres-ChávezJosé Bargas

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