Dopaminergic drug response and the genotype (Taq IA polymorphism) of the dopamine D2 receptor

The International Journal of Neuropsychopharmacology
Ivan BerlinAlain J. Puech

Abstract

The genotype of the receptor with which a particular drug interacts may be a between- subject factor that modifies the pharmacodynamic and consequently the therapeutic response to drugs. Subjects with A1 allele (Taq IA restriction fragment length polymorphism) of the gene encoding for the dopamine D2 receptor (DRD2) seem to express lower number of DRD2 compared to subjects who do not have this allele. We investigated whether subjects homozygous for the A1 allele of the DRD2 gene have decreased response to DRD2 stimulation by apomorphine when compared with those homozygous for the A2 allele. Two hundred and two Caucasian subjects were genotyped for DRD2 Taq IA polymorphism, 6.9 % had the genotype A1A1 and 65% A2A2. Nine homozygous subjects/group were selected for the apomorphine study. Five, 10 and 20 &mgr;g/kg of apomorphine were administered subcutaneously according to a randomized crossover design. The main pharmacodynamic criterion was the plasma growth hormone increase induced by apomorphine. Secondarily, we measured oral temperature responses and yawns in response to apomorphine. Plasma apomorphine concentrations were similar for the two matched and only genotypically different groups. Apomorphine dose-dependently increase...Continue Reading

Citations

Sep 30, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ivan BerlinDean Hamer
Oct 3, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael LuchtPrzemysław Bieńkowski
Aug 14, 2003·Fundamental & Clinical Pharmacology·Guy AymardBertrand Diquet
Jul 29, 2010·Critical Reviews in Toxicology·Gary GinsbergBabasaheb Sonawane

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