Dopaminergic dysregulation and impaired associative learning behavior in zebrafish during chronic dietary exposure to selenium

Environmental Pollution
Mohammad NaderiDouglas P Chivers

Abstract

A growing body of evidence indicates that exposure to selenium (Se) can cause neurotoxicity, and this can occur because of its interference with several neurotransmitter systems in humans and animals. Dopamine is a critical modulator of a variety of brain functions and a prime target for environmental neurotoxicants. However, effects of environmentally relevant concentrations of Se on dopaminergic system and its neurobehavioral effects are still largely unknown. For this purpose, we exposed zebrafish, a model organism, to different concentrations of dietary l-selenomethionine (control, 3.5, 11.1, 27.4, and 63.4 μg Se/g dry weight) for a period of 60 days. Cognitive performance of fish was evaluated using a plus maze associative learning paradigm. Oxidative stress, as the main driver of Se neurotoxicity, was assessed by measuring the ratio of reduced to oxidized glutathione (GSH:GSSG), lipid peroxidation (LPO) levels, and mRNA expression of several antioxidant enzymes in the zebrafish brain. Dopamine levels in the brain and the expression of genes involved in dopamine synthesis, storage, reuptake, metabolism, and receptor activation were examined. Moreover, transcription of several synaptic plasticity-related immediate-early and...Continue Reading

Citations

Jul 8, 2020·Antioxidants·Han-A Park, Amy C Ellis
Oct 4, 2018·Current Environmental Health Reports·Marco VincetiLauren A Wise
Mar 7, 2019·Archives of Environmental Contamination and Toxicology·Philip J AndersonMaud C O Ferrari
Dec 2, 2020·Environmental Pollution·Ayaat T Hassan, Raymond W M Kwong
Jan 15, 2021·The Science of the Total Environment·Mohammad NaderiRaymond W M Kwong
Jun 5, 2021·Neuroscience and Biobehavioral Reviews·Radharani BenvenuttiAngelo Piato

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