Dopaminergic gene methylation is associated with cognitive performance in a childhood monozygotic twin study

Epigenetics : Official Journal of the DNA Methylation Society
Candace R LewisKathryn Lemery-Chalfant

Abstract

Individual differences in cognitive function are due to a combination of heritable and non-heritable factors. A large body of evidence from clinical, cognitive, and pharmacological neuroscience implicates dopaminergic gene variants as modulators of cognitive functions. Neuroepigenetic studies demonstrate environmental factors also influence complex phenotypes by affecting gene expression regulation. To evaluate the mechanism of environmental influence on cognitive abilities, we examined if epigenetic regulation of dopaminergic genes plays a role in cognition. Using a DNA methylation profiling microarray, we used a monozygotic (MZ) twin difference design to evaluate if co-twin differences in methylation of CpG sites near six dopaminergic genes predicted differences in response inhibition and memory performance. Studying MZ twins allows us to assess if environmentally driven differences in methylation affect differences in phenotype while controlling for the influence of genotype and shared family environment. Response inhibition was assessed with the flanker task and short-term and working memory were assessed with digit span recall. We found MZ co-twin differences in DRD4 gene methylation predicted differences in short-term mem...Continue Reading

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Methods Mentioned

BETA
PCA
Dissection

Software Mentioned

Psychology Experiment Building Language ( PEBL )
The
minfi
R package
LISAS
R
EpiDISH Epigenetic
IDAT

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