Dopaminergic innervation of the cerebral cortex: unexpected differences between rodents and primates

Trends in Neurosciences
B BergerC Verney

Abstract

Until recently, views on the organization and role of the mesotelencephalic dopaminergic (DA) systems were mostly based on studies of rodents, and it was assumed that homology existed across mammalian species. However, recent studies of both human and non-human primates indicate that this might not be so. The mesocortical DA system in primates, which is directly involved in the pathophysiology of severe illnesses such as Parkinson's disease and psychoses, shows substantial differences from that of rodents. These differences include much larger, re-organized terminal fields, a different phenotype for the co-localization of neuropeptides and a very early prenatal development.

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Related Concepts

Establishment and Maintenance of Localization
Prenatal Development
Muscle Innervation, Function
Family Dipodidae
Nerve Supply
Prenatal Development Aspects
Primates
Parkinson Disease
Physiopathological
Insula of Reil

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