Dopaminergic Input to the Inferior Colliculus in Mice

Frontiers in Neuroanatomy
Alexander A NevueC V Portfors

Abstract

The response of sensory neurons to stimuli can be modulated by a variety of factors including attention, emotion, behavioral context, and disorders involving neuromodulatory systems. For example, patients with Parkinson's disease (PD) have disordered speech processing, suggesting that dopamine alters normal representation of these salient sounds. Understanding the mechanisms by which dopamine modulates auditory processing is thus an important goal. The principal auditory midbrain nucleus, the inferior colliculus (IC), is a likely location for dopaminergic modulation of auditory processing because it contains dopamine receptors and nerve terminals immunoreactive for tyrosine hydroxylase (TH), the rate-limiting enzyme in dopamine synthesis. However, the sources of dopaminergic input to the IC are unknown. In this study, we iontophoretically injected a retrograde tracer into the IC of mice and then stained the tissue for TH. We also immunostained for dopamine beta-hydroxylase (DBH), an enzyme critical for the conversion of dopamine to norepinephrine, to differentiate between dopaminergic and noradrenergic inputs. Retrogradely labeled neurons that were positive for TH were seen bilaterally, with strong ipsilateral dominance, in the...Continue Reading

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Citations

Nov 19, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Fatemeh MollaeiVincent L Gracco
Jun 20, 2020·PLoS Biology·Catalina Valdés-BaizabalManuel S Malmierca
Jul 26, 2018·Frontiers in Neural Circuits·Simon N Jacob, Hendrikje Nienborg
Aug 12, 2016·The Journal of Comparative Neurology·Giedre MilinkeviciuteDavid K Ryugo
Apr 5, 2018·Frontiers in Neuroanatomy·Melanie Haehnel-TaguchiWolfgang Driever
Oct 18, 2020·The Journal of Comparative Neurology·Charles A WilliamsDavid J Perkel
Jun 18, 2019·Current Biology : CB·Jonathan T PerelmuterPaul M Forlano

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