Dopaminergic mechanism for caffeine-produced cocaine seeking in rats

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Thomas A Green, Susan Schenk

Abstract

Systemic administration of caffeine reinstates extinguished cocaine self-administration behavior in rats, but the mechanism mediating this behavioral effect has not been established. The present study examined the role of adenosinergic A2 and dopaminergic mechanisms in caffeine-produced cocaine seeking. Following extinction of cocaine self-administration, experimenter-administered injections of caffeine (1.25-20 mg/kg) and theophylline (1-10 mg/kg) dose-dependently reinstated extinguished cocaine-seeking behavior. Administration of the adenosinergic A2 antagonist, 3,7-dimethyl-1-propargylxanthine (DMPX; 0.546-2.18 microg/kg), failed to produce cocaine seeking. Pretreatment with doses of the adenosine A1/A2 agonist 5'-N-ethylcarboxamidoadenosine (NECA; 0.003-0.03 mg/kg) that were below those that produced marked sedation failed to block reinstatement. These data suggest that methylxanthine-produced cocaine seeking is not due to adenosine A2 receptor antagonism. In contrast, pretreatment with the dopaminergic D1-like antagonist SCH 23390 (0.005-0.02 mg/kg) or the D2-like antagonist eticlopride (0.03-0.3 mg/kg) produced a dose-dependent attenuation of caffeine-produced reinstatement at doses that did not decrease cocaine self-admi...Continue Reading

Citations

Dec 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Casey E O'NeillRyan K Bachtell
Mar 16, 2005·Behavioural Pharmacology·O Cauli, M Morelli
Sep 13, 2011·Progress in Neurobiology·Geoffrey BurnstockPeter Illes
Mar 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hiroshi UjikeShigetoshi Kuroda
Sep 15, 2004·Alcoholism, Clinical and Experimental Research·Maria Pia ArolfoPatricia H Janak
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Mar 24, 2016·Pharmacology, Biochemistry, and Behavior·Natashia SwalveMarilyn E Carroll
Dec 30, 2011·Computers in Biology and Medicine·Carlos Fernando Crispim JuniorJosé Marino-Neto
Apr 12, 2015·Drug and Alcohol Dependence·Rebecca McKetinSharlene Kaye
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Feb 22, 2011·Pharmacology, Biochemistry, and Behavior·Caleb Carati, Susan Schenk
Nov 1, 2015·Neuropharmacology·Ute Krügel
Jun 24, 2009·The International Journal of Neuropsychopharmacology·Nicola SimolaTimothy Schallert

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