PMID: 6109764Feb 1, 1981Paper

Dopaminergic mechanisms in the teleost retina. I. Dopamine-sensitive adenylate cyclase in homogenates of carp retina; effects of agonists, antagonists, and ergots

Journal of Neurochemistry
K J Watling, J E Dowling

Abstract

A specific dopamine-sensitive adenylate cyclase has been identified in homogenates of the teleost (carp) retina. Maximal stimulation by 100 microM-dopamine resulted in a 5--10-fold increase in adenylate cyclase activity with half-maximal stimulation occurring at a concentration of 1 microM. l-Noradrenaline and l-adrenaline were some 10 times less potent than dopamine whilst the alpha- and beta-adrenoreceptor agonists, l-phenylephrine and dl-isoprenaline were inactive. Apomorphine elicited a partial stimulation of adenylate cyclase activity whilst various ergot alkaloids produced mixed agonist/antagonist responses. Dopamine-stimulated adenylate cyclase activity was potently antagonised by various neuroleptic drugs including fluphenazine, alpha-flupenthixol and alpha-piflutixol, and to a lesser extent by the butyrophenone derivatives haloperidol and spiperone. The benzamide derivatives, metoclopramide and sulpiride, together with the alpha- and beta-adrenoreceptor blocking agents, phentolamine and propranolol respectively were essentially inactive at blocking dopamine-stimulated adenylate cyclase activity. These data suggest the presence of a highly specific dopamine-sensitive adenylate cyclase in homogenates of teleost retina po...Continue Reading

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Citations

Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
Sep 18, 2018·Annual Review of Vision Science·John E Dowling
Jan 1, 1987·Journal of Neural Transmission·D J PettiboneB V Clineschmidt
Sep 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·J F PlantjéJ C Stoof
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Jan 1, 1987·Journal of Neuroscience Research·E H JafféB D Drujan
Jul 1, 1994·Visual Neuroscience·Z S Lin, S Yazulla
Dec 1, 1990·Journal of Neurochemistry·A J BalmforthS G Ball
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Dec 3, 1984·Life Sciences·J C Stoof, J W Kebabian
Jan 1, 1994·Pharmacology & Therapeutics·D M Jackson, A Westlind-Danielsson
Dec 23, 1985·Brain Research·D R O'Brien, J E Dowling
Feb 26, 1986·Brain Research·C BlazynskiJ A Ferrendelli
Jan 1, 1983·Vision Research·G L FainS Callery
Feb 1, 1992·Neurochemistry International·M B Djamgoz, H J Wagner

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