Dopaminergic modulation of human bronchial tone

Archives of Medical Research
G A CabezasM Velasco

Abstract

Dopamine exerts inhibitory and excitatory effects on different systems. Its effect on human bronchial tone is controversial. It has been reported that dopamine has no acute effect on human airways from normal subjects or those with asthma background. However, inhaled or infused dopamine decreased histamine-induced bronchoconstriction in both normal and asthmatic subjects. We examined the possible modulating effect of dopamine on bronchial diameter by administering inhaled dopamine and the DA(2) dopaminergic blocker metoclopramide (MTC) to subjects with various degrees of bronchial tone. We examined 50 volunteers. Arterial blood pressure and heart rate were determined in each subject. By means of spirometry, we measured forced vital capacity (FVC), forced expiratory volume in the first second (FEV(1)), maximal forced expiratory flow (FEF(max)), and forced expiratory flow at 50% of vital capacity (FEF(50)), before and after each treatment. By inhalation with a nebulizer, we administered the following: a) dopamine (0.5 microg/kg/min) to 10 healthy subjects, 10 subjects with asthma without acute bronchospasm (AWAB), and nine subjects with acute asthma attack (AAA), and b) intravenous (i.v.) metoclopramide (7 microg/kg/min) was admi...Continue Reading

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Citations

May 25, 2010·American Journal of Therapeutics·Gloria A Cabezas, Manuel Velasco
Oct 4, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kentaro MizutaCharles W Emala
Aug 9, 2011·BMC Psychiatry·Ole Bernt FasmerJan Haavik
Dec 8, 2006·Pulmonary Pharmacology & Therapeutics·Agnieszka CiarkaPhilippe van de Borne
Sep 25, 2016·Journal of Attention Disorders·Johanne Telnes InstanesJan Haavik

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