Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression

Parkinson's Disease
Anders H AndersenLee X Blonder

Abstract

Parkinson's disease (PD) is associated with emotional abnormalities. Dopaminergic medications ameliorate Parkinsonian motor symptoms, but less is known regarding the impact of dopaminergic agents on affective processing, particularly in depressed PD (dPD) patients. The aim of this study was to examine the effects of dopaminergic pharmacotherapy on brain activation to emotional stimuli in depressed versus nondepressed Parkinson disease (ndPD) patients. Participants included 18 ndPD patients (11 men, 7 women) and 10 dPD patients (7 men, 3 women). Patients viewed photographs of emotional faces during functional MRI. Scans were performed while the patient was taking anti-Parkinson medication and the day after medication had been temporarily discontinued. Results indicate that dopaminergic medications have opposite effects in the prefrontal cortex depending upon depression status. DPD patients show greater deactivation in the ventromedial prefrontal cortex (VMPFC) on dopaminergic medications than off, while ndPD patients show greater deactivation in this region off drugs. The VMPFC is in the default-mode network (DMN). DMN activity is negatively correlated with activity in brain systems used for external visual attention. Thus dopam...Continue Reading

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Citations

Sep 1, 2017·Brain Imaging and Behavior·Mikaeel ValliAntonio P Strafella
Aug 3, 2019·Physiological Genomics·Pan XuHui Lu

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Methods Mentioned

BETA
pharmacotherapy
genotyping

Software Mentioned

Oxford Center for Functional Magnetic Resonance Imaging of the...
Analysis of Functional Neuroimages ( AFNI )
Prime
SAS
FreeSurfer

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