Dopaminergic modulation of the voltage-gated sodium current in the cochlear afferent neurons of the rat

PloS One
Catalina Valdés-BaizabalRosario Vega

Abstract

The cochlear inner hair cells synapse onto type I afferent terminal dendrites, constituting the main afferent pathway for auditory information flow. This pathway receives central control input from the lateral olivocochlear efferent neurons that release various neurotransmitters, among which dopamine (DA) plays a salient role. DA receptors activation exert a protective role in the over activation of the afferent glutamatergic synapses, which occurs when an animal is exposed to intense sound stimuli or during hypoxic events. However, the mechanism of action of DA at the cellular level is still not completely understood. In this work, we studied the actions of DA and its receptor agonists and antagonists on the voltage-gated sodium current (INa) in isolated cochlear afferent neurons of the rat to define the mechanisms of dopaminergic control of the afferent input in the cochlear pathway. Experiments were performed using the voltage and current clamp techniques in the whole-cell configuration in primary cultures of cochlear spiral ganglion neurons (SGNs). Recordings of the INa showed that DA receptor activation induced a significant inhibition of the peak current amplitude, leading to a significant decrease in cell excitability. I...Continue Reading

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Citations

Jan 7, 2016·Frontiers in Cellular Neuroscience·Antonia González-GarridoEnrique Soto
Dec 10, 2015·Molecular Genetics and Metabolism·Gabriella A HorvathClara D M van Karnebeek
Jan 25, 2017·The Journal of Comparative Neurology·Jonathan T Perelmuter, Paul M Forlano
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Oct 14, 2019·Neuroscience Bulletin·Ning YinZhongfeng Wang
Jul 16, 2020·Journal of Neurophysiology·Frances L Meredith, Katherine J Rennie
Nov 30, 2018·Frontiers in Cellular Neuroscience·Frances L Meredith, Katherine J Rennie
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Jun 2, 2020·Frontiers in Systems Neuroscience·Liqiang FanJian Wang
Jun 18, 2019·Current Biology : CB·Jonathan T PerelmuterPaul M Forlano
Jun 11, 2021·Hearing Research·Siân R KitcherCatherine J C Weisz

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Methods Mentioned

BETA
glycosylation
bioluminescence resonance energy transfer
co-immunoprecipitation

Software Mentioned

Origin
pCLAMP
OriginPro
Clampfit

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