Dopaminergic neurotransmission in patients with schizophrenia in relation to positive and negative symptoms

Pharmacopsychiatry
O PogarellH-J Möller

Abstract

Schizophrenia is a complex dynamic disorder comprising a wide range of neurobiological alterations including dopaminergic dysfunction. The aim of the study was to investigate dynamic changes of dopaminergic neurotransmission in patients with schizophrenia (n=8, mean age 25.4 ± 5.8 years) in early stages of the disorder, compared to healthy control subjects (n=7, mean age 23.6 ± 2.7 years). A dynamic IBZM SPECT protocol was used to assess the endogenous dopamine release following an amphetamine challenge. Subjects received a bolus activity of 175 MBq followed by a continuous infusion of 45 MBq/h [123I]IBZM. SPECT scans were performed 2 h after bolus injection, and 1 h following the amphetamine challenge (0.3 mg/kg). Striatal IBZM binding to dopamine D2 receptors was assessed with a volume-of-interest (VOI) technique. The change in IBZM binding between pre- and post-challenge scans was used as a measure of endogenous dopamine release triggered by amphetamine. At baseline, patients showed higher mean striatal IBZM binding compared to controls (0.77 ± 0.09 vs. 0.68 ± 0.07, p=0.07). There was a statistically significant difference in IBZM binding between patients, with a predominance of negative vs. positive symptoms (0.84 ± 0.08 vs...Continue Reading

Citations

May 22, 2016·Biological Psychiatry·Jodi J WeinsteinAnissa Abi-Dargham
Jun 20, 2015·Frontiers in Endocrinology·Megan Elizabeth Rich, Heather Kingsley Caldwell
May 15, 2016·Biochimica Et Biophysica Acta·Zhen QiEberhard O Voit
Oct 11, 2016·Biological Psychiatry·Oliver D HowesRobin M Murray
Sep 7, 2016·Schizophrenia Research·Orwa DandashAlex Fornito
Jan 15, 2015·Journal of Psychopharmacology·Oliver HowesJames Stone
Jun 13, 2015·Clinical Microbiology Reviews·Chia-Kwung FanUrsula Barghouth
Jul 6, 2020·Lipids in Health and Disease·Mei-Chi HsuWen-Chen Ouyang
Dec 4, 2019·Neuroscience and Biobehavioral Reviews·Benjamín RodríguezMirian A F Hayashi

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