Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone

The European Journal of Neuroscience
Sarah A BakerTheo Hagg

Abstract

An understanding of the regulators of neurogenesis in the normal and diseased brain is necessary in order to recruit endogenously produced neural precursors for cell replacement in neurodegenerative disorders such as Parkinson's disease. The location of dopaminergic projections from the midbrain to the neostriatum and nucleus accumbens overlaps with the most active region of neurogenesis in the adult brain, the subventricular zone of the anterior lateral ventricle. This suggests that dopamine may contribute to regulation of the subventricular niche of adult neurogenesis. Here, we show in adult mice that destruction of the dopaminergic neurons in the substantia nigra and ventral tegmental area in a 6-hydroxydopamine model of Parkinson's disease reduced the number of proliferating neural precursors in the subventricular zone of the anterior lateral ventricle by approximately 40%. The effect on neural precursor proliferation correlated with the extent of dopaminergic denervation in the neighboring neostriatum. This identifies dopamine as one of the few known endogenous regulators of adult neurogenesis with implications for the potential use of endogenous neural precursors in cell replacement strategies for Parkinson's disease.

References

May 20, 1994·Science·C Lois, A Alvarez-Buylla
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C Lois, A Alvarez-Buylla
Jan 29, 2000·Brain Research. Molecular Brain Research·S LinnarssonP Ernfors
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·G GheusiP M Lledo
Feb 24, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·G TissinghE C Wolters
Nov 28, 2001·The European Journal of Neuroscience·M BanasrA Daszuta
Mar 19, 2002·Journal of Neuroscience Methods·N KeeJ M Wojtowicz
Sep 14, 2002·Science·Miguel Ramalho-SantosDouglas A Melton

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Citations

Oct 9, 2007·Cell and Tissue Research·Joanne C Conover, Ryan Q Notti
Dec 23, 2011·Cellular and Molecular Neurobiology·Keiji MoriAkira Ota
Mar 10, 2005·Neurobiology of Disease·Sarah A BakerTheo Hagg
Aug 21, 2007·Nature Reviews. Neuroscience·Maurice A CurtisPeter S Eriksson
Aug 2, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caterina BreitensteinStefan Knecht
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gráinne C O'KeeffeMaeve A Caldwell
Jul 19, 2006·Stem Cells and Development·Wendy PhillipsRoger A Barker
Feb 6, 2008·Stem Cells and Development·Theodora PapanikolaouJoanne C Conover
Nov 15, 2011·Brain : a Journal of Neurology·Simone A van den BergeElly M Hol
Apr 28, 2012·Brain : a Journal of Neurology·Günter U HöglingerEtienne C Hirsch
Feb 27, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Patricio A RiquelmeFiona Doetsch
Feb 23, 2011·Development, Growth & Differentiation·Woon Ryoung Kim, Woong Sun
May 23, 2012·Pharmacological Reviews·Van A Doze, Dianne M Perez
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Aug 16, 2012·Stem Cell Research & Therapy·Maik Ma WorlitzerJens C Schwamborn
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica B LenningtonJoanne C Conover
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jordi BovéSerge Przedborski
Mar 18, 2008·Neurosurgical Focus·Arnar AstradssonOle Isacson
May 30, 2013·Development·Daniel A BergAndrás Simon
Jul 7, 2012·Cellular and Molecular Life Sciences : CMLS·Franz MarxreiterJürgen Winkler
Feb 12, 2013·Cellular and Molecular Life Sciences : CMLS·Jean-Claude Platel, Wolfgang Kelsch
Jan 26, 2016·Neuroscience Letters·Joshua E AlbrightBrad E Morrison
Jan 24, 2016·Brain Research·Deana M AppleErzsebet Kokovay
Feb 3, 2016·Frontiers in Cellular Neuroscience·Luis Federico BátizUrsula Wyneken
Dec 12, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kasturi BanerjeeJohn W Cave
Jun 27, 2012·Progress in Neurobiology·Karlijn J DoornAnne-Marie van Dam
Dec 24, 2011·Neurobiology of Disease·Richard L Doty
Jun 7, 2011·Journal of Chemical Neuroanatomy·Serena BovettiAldo Fasolo
Mar 2, 2010·Brain Research Reviews·Jean-Claude PlatelAngélique Bordey
Jan 19, 2010·Experimental Neurology·June-Hee Park, Grigori Enikolopov
Jan 26, 2008·Journal of Neuropathology and Experimental Neurology·Beate WinnerJürgen Winkler
Jul 22, 2009·Experimental Neurology·Beate WinnerJürgen Winkler
Mar 3, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marta GrabiecRouzanna L Djavadian
May 12, 2009·Progress in Neurobiology·Myriam CayreJames E Goldman
Feb 6, 2007·Neurobiology of Aging·Beate WinnerJürgen Winkler

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