Dopaminergic regulation of AP-1 transcription factor DNA binding activity in rat striatum

Neuroscience
K X Huang, J R Walters

Abstract

Dopaminergic modulation of the DNA binding activity of AP-1, Sp1, CREB and AP-2 transcription factors was examined in rat striatal nuclear extracts by gel shift assay. AP-1 binding was selectively increased in the striatum following depletion of dopamine by 6-hydroxydopamine-induced lesion of the nigrostriatal pathway or after reserpine treatment. The D1 agonist SKF 38393 dose-dependently increased AP-1 binding; this effect was significantly increased in reserpine-treated rats and even more markedly enhanced in denervated striatum. The D2/D3 agonist quinpirole, administered alone, did not affect striatal activator protein-1 binding; in combination, quinpirole and SKF 38393 acted synergistically in normal and reserpine-treated rats but not in 6-hydroxydopamine-lesioned rats, suggesting that mechanisms underlying D1-D2/D3 interactions are altered after dopamine denervation. Most, but not all, of the changes in AP-1 binding activity observed in this study are consistent with changes in levels of Fos/Jun family proteins observed after similar treatments. These results support the hypothesis that D1 receptor stimulation activates striatonigral neurons and modulates expression of AP-1-related genes in these neurons, while D2 receptor...Continue Reading

References

May 1, 1992·Brain Research. Molecular Brain Research·P HughesM Dragunow
Sep 1, 1992·Brain Research. Molecular Brain Research·K R PennypackerJ S Hong
Apr 1, 1992·Journal of Neurochemistry·A J ColeJ M Baraban
Sep 1, 1992·Brain Research Bulletin·P Rogue, G Vincendon
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T V NguyenS E Hyman
Apr 1, 1992·Trends in Neurosciences·C R Gerfen
Sep 15, 1992·Biochemistry·T MinowaM M Mouradian
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J M Berg
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B HopeE J Nestler
Aug 7, 1992·Cell·T Hunter, M Karin
Jul 1, 1990·Trends in Neurosciences·G E Alexander, M D Crutcher
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L A KobierskiM J Comb
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S T YoungM J Iadarola
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K A NeveG A Higgins
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T Hai, T Curran
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C Le MoineB Bloch
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J YenI M Verma
Apr 1, 1991·Molecular and Cellular Biology·J D SafferM B Annarella
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M GraybielH A Robertson
Sep 21, 1990·European Journal of Pharmacology·H CoiriniB S McEwen
Jul 23, 1990·Brain Research·G S RobertsonH C Fibiger
Oct 1, 1990·Brain Research·M B HarrisonG F Wooten
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C Le MoineB Bloch
Nov 1, 1989·Trends in Neurosciences·J I Morgan, T Curran
Jan 2, 1989·European Journal of Pharmacology·G S RobertsonH A Robertson
Dec 22, 1989·Science·J L SonnenbergT Curran

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Citations

Oct 7, 1998·Epilepsy Research·C DeransartA Depaulis
Jul 8, 1998·Artificial Intelligence in Medicine·R Kötter, J Wickens
Oct 6, 2009·Pharmacology, Biochemistry, and Behavior·Alexia E Pollack, Lindsay I Thomas
Mar 17, 2010·Brain Research·John F EnwrightColleen A McClung
Jun 3, 1998·Molecular and Cellular Neurosciences·U SchmidtC Beyer

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